Wolf H. research interests have been focused around the role of the immune system in controlling human tumors and the biological functions of receptors for IgG antibodies, both through basic and translational approaches.
His main contributions in cancer immunology stand up to 1969 when he published, with François Kourilsky, the first demonstration of an immune response of the patient to his own cancer, in acute leukemia. He, then, focused on the analysis of the tumor microenvironment with the demonstration of the beneficial effect of a Th1 oriented immune response to control clinical outcome in cervical cancer. Since 2005, the studies of Jérôme Galon, Franck Pagès and Wolf H. Fridman have changed the paradigm of host/cancer interactions by demonstrating that the ‘immune contexture”, taking in account the functionality, the location and the density of the immune infiltrate in colorectal tumors, is the major prognostic factor for human cancers. These findings really open the way for immune-based tools for efficient prognosis and therapy of cancers. His papers has been cited over 10.000 times and his i. Factor is 55. He is a world leader in the field of human tumor immunology as assessed by its recurrent invitations as Symposium Speaker to AACR, Keystone, FASEB and other top international meetings.