基本信息
views: 185
Career Trajectory
Bio
Focus of research
RNA biology using experimental and biocomputational approaches
Microbial systems biology
Biology of native CRISPR systems and their application
FRIAS Research Project
MapRNA: Mapping RNA-RNA pairings in vivo in bacteria and their importance in fast acclimation processes
The project “MapRNA” combines innovative technologies to generate complete maps of interactions between small non-coding RNAs (sRNAs) and their targets in two different bacteria, Staphylococcus aureus as a major pathogen and Synechocystis 6803, as a major model for prokaryotic photosynthetic biotechnology. Particularly, methicillin-resistant S. aureus (MRSA) strains at the hospital are a major life-threatening problem causing about 25,000 deaths per year in Europe, but community-associated MRSA strains appear even more virulent and transmissible.
Bacteria possess a large number of regulatory sRNAs that are key players in biological signaling networks. However, they are less well studied than regulatory proteins because their direct targets are difficult to identify. The two MapRNA partner groups will combine their complementary expertise at the interface of bioinformatics, experimental RNA biology, and microbial system biology to fundamentally improve this situation. The results will allow deep insight into the regulatory mechanisms at the molecular level and help to identify novel therapeutical targets and to enhance the yield from photobiotechnology.
MapRNA will deepen the already excellent relationship between the Universities of Strasbourg and of Freiburg and will promote the mobility and interculturality between our students and researchers contributing to the spirit of the European Campus.
RNA biology using experimental and biocomputational approaches
Microbial systems biology
Biology of native CRISPR systems and their application
FRIAS Research Project
MapRNA: Mapping RNA-RNA pairings in vivo in bacteria and their importance in fast acclimation processes
The project “MapRNA” combines innovative technologies to generate complete maps of interactions between small non-coding RNAs (sRNAs) and their targets in two different bacteria, Staphylococcus aureus as a major pathogen and Synechocystis 6803, as a major model for prokaryotic photosynthetic biotechnology. Particularly, methicillin-resistant S. aureus (MRSA) strains at the hospital are a major life-threatening problem causing about 25,000 deaths per year in Europe, but community-associated MRSA strains appear even more virulent and transmissible.
Bacteria possess a large number of regulatory sRNAs that are key players in biological signaling networks. However, they are less well studied than regulatory proteins because their direct targets are difficult to identify. The two MapRNA partner groups will combine their complementary expertise at the interface of bioinformatics, experimental RNA biology, and microbial system biology to fundamentally improve this situation. The results will allow deep insight into the regulatory mechanisms at the molecular level and help to identify novel therapeutical targets and to enhance the yield from photobiotechnology.
MapRNA will deepen the already excellent relationship between the Universities of Strasbourg and of Freiburg and will promote the mobility and interculturality between our students and researchers contributing to the spirit of the European Campus.
Research Interests
Papers共 330 篇Author StatisticsCo-AuthorSimilar Experts
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期刊级别
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合作机构
Manuel Brenes-Álvarez, Halie R. Ropp, Dimitrios Papagiannidis,Clement Potel,Frank Stein,Mikhail M Savitski,Agustín Vioque,Alicia M. Muro-Pastor,Wolfgang R. Hess
crossref(2024)
Nils Schmidt, Nils Stappert, Kaori Nimura-Matsune, Satoru Watanabe, Roman Sobotka, Martin Hagemann,Wolfgang R. Hess
biorxiv(2024)
Green Carbon (2024)
Journal of experimental botanyno. 11 (2024): 3206-3208
biorxiv(2024)
Ute A. Hoffmann,Elisabeth Lichtenberg, Said N. Rogh, Raphael Bilger,Viktoria Reimann, Florian Heyl,Rolf Backofen,Claudia Steglich,Wolfgang R. Hess, Annegret Wilde
RNA BIOLOGYno. 1 (2024): 1-18
Kazuma Ohdate, Minori Sakata,Kaisei Maeda,Yutaka Sakamaki,Kaori Nimura-Matsune,Ryudo Ohbayashi,Wolfgang R. Hess,Satoru Watanabe
Frontiers in microbiology (2024)
Nature Communicationsno. 1 (2024): 1-14
New phytologistno. 3 (2023): 1083-1097
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Author Statistics
#Papers: 329
#Citation: 19001
H-Index: 68
G-Index: 129
Sociability: 7
Diversity: 0
Activity: 2
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