Professor Lorenzon works in unpolarized and polarized hadronic physics as a member of the Seaquest collaboration at Fermilab. He has served as a Deputy Spokesman for HERMES from 1997-1998. For the Seaquest experiment, he has built the cryogenic targets and is studying the antiquark distribution in the nucleon sea to gain a better understanding of the model that describes nucleons. He received Stage 1 approval for the polarized beam Drell-Yan experiment E-2017 at Fermilab to study a fundamental prediction of QCD, which is expected to run after the polarized target Drell-Yan experiment E-1039 has finished data collection in 2020.

He is also working on Dark Matter direct detection. He has participated in the PandaX experiment in China for several years before joining the LZ Dark Matter experiment at the SURF laboratory in South Dakota in 2015. The LZ detector is the most ambitious and most advanced Dark Matter direct detection experiment, designed to observe WIMPs with a 10 ton liquid xenon detector. It is scheduled to start collecting science data in late 2019. For LZ, he is responsible for the in-line radon removal system for the central time-projection chamber which helps to increase the science reach of the LZ detector.

Just recently, Professor Lorenzon joined the MUSE experiment at the PSI laboratory in Switzerland. The MUSE experiment aims to resolve the unexplained large discrepancies of the proton charge radius measurements made with muonic hydrogen and electron-proton scattering. For MUSE, he is providing the liquid hydrogen target which builds on the expertise the group has gained over the past years.

Professor Lorenzon is a Fellow of the American Physical Society.