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Protein misfolding and human disease
Conversion of genetic information into functional protein products requires the proper folding of polypeptide chains in the crowded intracellular environment. Disruption of these folding pathways through exposure to either environmental or genetic factors is associated with numerous human diseases – collectively referred to as protein misfolding diseases. Using proteomic, biophysical and cell biological approaches, work in the Wiseman lab is directed towards understanding the physical, chemical and biological factors that dictate intracellular protein folding as it relates to human disease. Currently, we have three ongoing projects focused on protein folding in vivo: 1) development of novel biosensors that report on protein folding in the complex intracellular environment; 2) characterization of mitochondrial folding efficiency in the context of neurodegenerative disease; and 3) elucidation of the impact of intracellular signaling pathways on protein folding and trafficking in the early secretory pathway.
Protein misfolding and human disease
Conversion of genetic information into functional protein products requires the proper folding of polypeptide chains in the crowded intracellular environment. Disruption of these folding pathways through exposure to either environmental or genetic factors is associated with numerous human diseases – collectively referred to as protein misfolding diseases. Using proteomic, biophysical and cell biological approaches, work in the Wiseman lab is directed towards understanding the physical, chemical and biological factors that dictate intracellular protein folding as it relates to human disease. Currently, we have three ongoing projects focused on protein folding in vivo: 1) development of novel biosensors that report on protein folding in the complex intracellular environment; 2) characterization of mitochondrial folding efficiency in the context of neurodegenerative disease; and 3) elucidation of the impact of intracellular signaling pathways on protein folding and trafficking in the early secretory pathway.
研究兴趣
论文共 162 篇作者统计合作学者相似作者
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Caroline Stanton, Chavin Buasakdi, Jie Sun, Ian Levitan, Prerona Bora,Sergei Kutseikin,R. Luke Wiseman,Michael J. Bollong
bioRxiv the preprint server for biology (2024)
bioRxiv the preprint server for biology (2024)
Kelsey R Baron, Samantha Oviedo, Sophia Krasny,Mashiat Zaman, Rama Aldakhlallah, Prakhyat Mathur,Gerald Pfeffer,Michael J Bollong,Timothy Shutt,Danielle A Grotjahn,R Luke Wiseman
bioRxiv the preprint server for biology (2024)
Journal of molecular and cellular cardiology/Journal of Molecular and Cellular Cardiology (2024): 12-24
Gabriel M. Kline,Nicole Madrazo, Christian M. Cole, Meera Pannikkat,Michael J. Bollong,Jessica D. Rosarda,Jeffery W. Kelly,R. Luke Wiseman
RSC Chemical Biologyno. 9 (2024): 866-876
ACS chemical biologyno. 2 (2024): 254-265
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 20 (2023)
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作者统计
#Papers: 160
#Citation: 7468
H-Index: 42
G-Index: 86
Sociability: 7
Diversity: 0
Activity: 2
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