William Shropshire - University of Texas MD Anderson Cancer Center

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Bio

My current research focuses on the molecular epidemiology and evolutionary trajectory of multi-drug resistant (MDR) Gram-negative pathogens. In particular, my T32 funded project aims to determine how extended-spectrum beta-lactamase (ESBL) positive Enterobacteriaceae can adapt to carbapenem antibiotics and ascertain the mechanisms, which contribute to progressive MDR phenotypes.

Research Interests

Papers共 44 篇Author StatisticsCo-AuthorSimilar Experts

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Selection for Robust Metabolism in Domesticated Yeasts is Driven by Adaptation to Hsp90 Stress

Natalia Condic,Hatim Amiji, Dipak Patel,William Charles Shropshire,Nejla Ozirmak Lermi, Youssef Sabha, Beryl John,Blake Hanson,Georgios Ioannis Karras

Science (New York, NY)no. 6707 (2024): eadi3048-eadi3048

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Comprehensive Assessment of Initial Adaptation of ESBL Positive ST131 Escherichia Coli to Carbapenem Exposure

William C Shropshire,Xinhao Song,Jordan Bremer,Seokju Seo,Susana Rodriguez,Selvalakshmi Selvaraj Anand,An Q Dinh,Micah M Bhatti,Anna Konovalova,Cesar A Arias,Awdhesh Kalia,Yousif Shamoo,Samuel A Shelburne

bioRxiv the preprint server for biology (2024)

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Structural Insights into the Molecular Mechanism of High-Level Ceftazidime–avibactam Resistance Conferred by CMY-185

Akito Kawai,William C. Shropshire,Masahiro Suzuki,Jovan Borjan,Samuel L. Aitken,William C. Bachman,Christi L. McElheny,Micah M. Bhatti,Ryan K. Shields,Samuel A. Shelburne,Yohei Doi

MBIOno. 2 (2024)

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Rapid Genomic Characterization of High-Risk, Antibiotic Resistant Pathogens Using Long-Read Sequencing to Identify Nosocomial

Chin-Ting Wu,Amy Spallone,Sherry Cantu,Todd Treangen,William Shropshire,Micah Bhatti,Israel Glover, Xiaojun Liu,Samuel Shelburne,Awdhesh Kalia

Antimicrobial Stewardship & Healthcare Epidemiology (2024): s106-s106

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Identification of a Novel CG307 Sub-Clade in Third-Generation-cephalosporin-resistant Klebsiella Pneumoniae Causing Invasive Infections in the USA

Selvalakshmi Selvaraj Anand,Chin -Ting Wu,Jordan Bremer,Micah Bhatti,Todd J. Treangen,Awdhesh Kalia,Samuel A. Shelburne,William C. Shropshire

MICROBIAL GENOMICSno. 2 (2024)

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Rapid Whole Genome Characterization of High-Risk Pathogens Using Long-Read Sequencing to Identify Potential Healthcare Transmission

Chin-Ting Wu,William C Shropshire,Micah M Bhatti,Sherry Cantu, Israel K Glover,Selvalakshmi Selvaraj Anand, Xiaojun Liu,Awdhesh Kalia,Todd J Treangen, Roy F Chemaly,Amy Spallone,Samuel Shelburne

medRxiv the preprint server for health sciences (2024)

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High-level ceftazidime/avibactam resistance in Escherichia coli conferred by the novel plasmid-mediated β-lactamase CMY-185 variant

William C Shropshire,Bradley T Endres,Jovan Borjan,Samuel L Aitken,William C Bachman,Christi L McElheny,Chin-Ting Wu,Stephanie L Egge,Ayesha Khan,William R Miller,Micah M Bhatti,Pranoti Saharasbhojane,Akito Kawai,Ryan K Shields,Samuel A Shelburne,Yohei Doi

Journal of Antimicrobial Chemotherapyno. 10 (2023): 2442-2450

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Ethanol Drives Evolution of Hsp90-Dependent Robustness by Redundancy in Yeast Domestication

Dipak Patel,Hatim Amiji,William Shropshire, Natalia Condic,Nejla Ozirmak Lermi, Youssef Sabha, Beryl John,Blake Hanson,Georgios Ioannis Karras

bioRxiv the preprint server for biology (2023)

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Temporal Dynamics of Genetically Heterogeneous Extended-Spectrum Cephalosporin Resistant Escherichia Coli Bloodstream Infections

William C. Shropshire,Benjamin Strope,Selvalakshmi Selvaraj Anand,Jordan Bremer,Patrick McDaneld,Micah M. Bhatti,Anthony R. Flores,Awdhesh Kalia,Samuel A. Shelburne

mSphere（2023）

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High-level ceftazidime/avibactam resistance in Escherichia coli conferred by the novel plasmid-mediated ?-lactamase CMY-185 variant

William C. Shropshire,Bradley T. Endres,Jovan Borjan,Samuel L. Aitken,William C. Bachman,Christi L. McElheny,Chin-Ting Wu,Stephanie L. Egge,Ayesha Khan,William R. Miller,Micah M. Bhatti,Pranoti Saharasbhojane,Akito Kawai,Ryan K. Shields,Samuel A. Shelburne,Yohei Doi

Journal of Antimicrobial Chemotherapyno. 10 (2023): 2442-2450

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