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The current objective of our laboratory is to determine the mechanisms used by B family DNA polymerases for base discrimination. We have selected a T even phage DNA polymerase, RB69 pol, as a prototype for several reasons: (i) it has considerable sequence similarities to human DNA pol a and d; (ii) it is assembled into a DNA replicase with accessory proteins in an analogous fashion to human DNA replicases; (iii) there is a wealth of structural and kinetic information about this enzyme that enables new findings about the mechanism of action of RB69 pol to be interpreted within a well established framework; (iv) despite extensive studies it is still unclear how RB69 as well as other DNA pols are able to replicate DNA with a minimum of errors (2x10-8 per base per genome replication).
Specialized Terms: Blood Coagulation; DNA Replication; Genetics; Proteins and Macromolecules
The current objective of our laboratory is to determine the mechanisms used by B family DNA polymerases for base discrimination. We have selected a T even phage DNA polymerase, RB69 pol, as a prototype for several reasons: (i) it has considerable sequence similarities to human DNA pol a and d; (ii) it is assembled into a DNA replicase with accessory proteins in an analogous fashion to human DNA replicases; (iii) there is a wealth of structural and kinetic information about this enzyme that enables new findings about the mechanism of action of RB69 pol to be interpreted within a well established framework; (iv) despite extensive studies it is still unclear how RB69 as well as other DNA pols are able to replicate DNA with a minimum of errors (2x10-8 per base per genome replication).
Specialized Terms: Blood Coagulation; DNA Replication; Genetics; Proteins and Macromolecules
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