In addition to the WHI, she has been principal investigator on dozens of research studies funded by the NIH and other federal agencies. Her interests include research on risk factors and prevention of cancer, osteoporosis and periodontal disease in postmenopausal women. Her current research focuses on the oral microbiome and health outcomes. She has also conducted several studies on reproductive health issues in younger women. As part of this work, she has led several large-scale prevention clinical trials in women.