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The Merrick laboratory seeks to identify all of the eukaryotic translation initiation factors and determine their sequential utilization in the initiation pathway. A secondary goal is to characterize how the initiation pathway is regulated and the different consequences depending on the exact point of regulation.
Current research is focusing on two major aspects of translation initiation, cap-dependent and cap-independent (or internal) initiation. Although much of the gross work has been determined using hemoglobin mRNA as a model mRNA, it has become clear that other elements influence both the regulation and mechanism of translation initiation in mammalian systems. Within the realm of cap-dependent translation, we are examining the influence of individual initiation factors on both overall affect on translation initiation and the affect of increased or decreased levels of initiation factors on start site selection in mRNAs containing in frame start sites which yield two proteins, one with a slightly longer N-terminal region than the other.
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Papers共 238 篇Author StatisticsCo-AuthorSimilar Experts
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Elsevier eBookspp.676-688, (2023)
R. Anderson, A. Agarwal,A. Ghosh,B. -J Guan, J. Casteel,N. Dvorina, W. M. Baldwin III, R. Mazumder,T. Y. Nazarko,W. C. Merrick,D. A. Buchner,M. Hatzoglou,R. Kondratov,A. A. Komar
Dawid Krokowski,Raul Jobava,Krzysztof J. Szkop,Chien-Wen Chen,Xu Fu,Sarah Venus,Bo-Jhih Guan,Jing Wu,Zhaofeng Gao, Wioleta Banaszuk,Marek Tchorzewski,Tingwei Mu, Phil Ropelewski,William C. Merrick,Yuanhui Mao,Aksoylu Inci Sevval,Helen Miranda,Shu-Bing Qian,Maria Manifava,Nicholas T. Ktistakis,Anastasios Vourekas,Eckhard Jankowsky,Ivan Topisirovic,Ola Larsson,Maria Hatzoglou
Raul Jobava,Yuanhui Mao,Bo-Jhih Guan,Di Hu,Dawid Krokowski,Chien-Wen Chen,Xin Erica Shu,Evelyn Chukwurah,Jing Wu,Zhaofeng Gao,Leah L. Zagore,William C. Merrick,Aleksandra Trifunovic,Andrew C. Hsieh,Saba Valadkhan,Youwei Zhang,Xin Qi,Eckhard Jankowsky,Ivan Topisirovic,Donny D. Licatalosi,Shu-Bing Qian,Maria Hatzoglou
pubmed(2020)
Cell reportsno. 8 (2020): 2481-2488.e5
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#Papers: 238
#Citation: 19927
H-Index: 78
G-Index: 137
Sociability: 6
Diversity: 3
Activity: 22
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