I direct one of the largest renal pathology laboratories in the country, which processes approximately 4800 renal biopsies annually. My major research interests are mechanisms of glomerular and tubulointerstitial injury in podocytopathies, immune mediated glomerulonephritis, and toxic tubulopathies. I am interested in how pathologic forms of injury manifest clinically, the pathogenetic mechanisms governing distinct morphologic patterns of injury, and how disease biomarkers can inform treatment and outcome in the individual patient. My basic research has focused primarily on mechanisms of podocyte dysregulation, injury and depletion in primary and secondary forms of FSGS and how such dysregulation promotes progressive CKD. My work in animal models has characterized molecular mechanisms of podocyte injury in HIVAN, primary FSGS and diabetic nephropathy.