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A native of Peru, Dr Vivanco received his BA in Molecular and Cellular Biology from the University of California at Berkeley, and his PhD in Molecular Biology from the University of California at Los Angeles. As a graduate student in the laboratory of Dr Charles Sawyers, Dr Vivanco became interested in a very peculiar characteristic of cancer cells known as oncogene addiction. Oncogene addiction is a cellular condition wherein a cancer cell, as a consequence of gene mutation and the subsequent rewiring of ill-defined molecular programs, becomes entirely dependent (or addicted) on the activity of a single gene product. Because this addiction is unique to cancer cells and is not seen in the remaining normal tissue from which the cancer arose, oncogene addiction provides a therapeutic opportunity for drugs that can turn off the activity of the addicting oncogene as they will not cause damage to normal cells.
During his graduate studies with Dr Sawyers, Dr Vivanco studied how a very common genetic alteration found in human cancer, namely the tumour suppressor PTEN, enhanced the dependence of cells on the activity of JNK kinases. He showed that drugs that inactivate JNK can inhibit the growth of PTEN-deficient cells while having minimal effects on PTEN-intact cells.
After receiving his PhD, Dr Vivanco continued to study oncogene addiction in the laboratory of Dr Ingo Mellighoff at Memorial Sloan Kettering Cancer Center, where he focused on understanding EGFR dependence in brain tumors and how to optimize pharmacological targeting of this commonly activated oncoprotein. His studies have provided proof-of-concept for ongoing clinical trials of EGFR inhibitors in glioblastoma.
In the last few years, Dr Vivanco has begun to characterize the molecular basis of addiction to the PI3K signalling pathway, which is altered in the majority of human cancers. He has identified a novel non-catalytic function of the serine-threonine kinase AKT, arguably the most important effector within this pathway, that is critical for promoting cell survival in specific genetic contexts. He hopes that by understanding the role of the various molecules within this pathway in cancer cell survival, he will be able to devise novel therapeutic strategies across a variety of cancer types.
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论文共 61 篇作者统计合作学者相似作者
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Cancer Researchno. 6_Supplement (2024): 7196-7196
Cancer Researchno. 6_Supplement (2024): 632-632
Igor Vivanco,H. Ian Robins,Daniel Rohle,Carl Campos,Christian Grommes,Phioanh Leia Nghiemphu,Sara Kubek,Barbara Oldrini,Milan G. Chheda,Nicolas Yannuzzi,Hui Tao,Shaojun Zhu,Akio Iwanami,Daisuke Kuga,Julie Dang,Alicia Pedraza,Cameron W. Brennan,Adriana Heguy,Linda M. Liau,Frank Lieberman,W. K. Alfred Yung,Mark R. Gilbert,David A. Reardon,Jan Drappatz,Patrick Y. Wen,Kathleen R. Lamborn,Susan M. Chang,Michael D. Prados,Howard A. Fine,Steve Horvath,Nian Wu,Andrew B. Lassman,Lisa M. DeAngelis,William H. Yong,John G. Kuhn,Paul S. Mischel,Minesh P. Mehta,Timothy F. Cloughesy,Ingo K. Mellinghoff
crossref(2023)
Igor Vivanco,H. Ian Robins,Daniel Rohle,Carl Campos,Christian Grommes,Phioanh Leia Nghiemphu,Sara Kubek,Barbara Oldrini,Milan G. Chheda,Nicolas Yannuzzi,Hui Tao,Shaojun Zhu,Akio Iwanami,Daisuke Kuga,Julie Dang,Alicia Pedraza,Cameron W. Brennan,Adriana Heguy,Linda M. Liau,Frank Lieberman,W. K. Alfred Yung,Mark R. Gilbert,David A. Reardon,Jan Drappatz,Patrick Y. Wen,Kathleen R. Lamborn,Susan M. Chang,Michael D. Prados,Howard A. Fine,Steve Horvath,Nian Wu,Andrew B. Lassman,Lisa M. DeAngelis,William H. Yong,John G. Kuhn,Paul S. Mischel,Minesh P. Mehta,Timothy F. Cloughesy,Ingo K. Mellinghoff
crossref(2023)
crossref(2023)
Sean R. Wallace,Khine Nyein Myint, Shihe Hou, Maria Zalath, Andrew Kwon, Brian McMorran,Igor Vivanco
Molecular cancer therapeuticsno. 12_Supplement (2023): A117-A117
Igor Vivanco,H. Ian Robins,Daniel Rohle,Carl Campos,Christian Grommes,Phioanh Leia Nghiemphu,Sara Kubek,Barbara Oldrini,Milan G. Chheda,Nicolas Yannuzzi,Hui Tao,Shaojun Zhu,Akio Iwanami,Daisuke Kuga,Julie Dang,Alicia Pedraza,Cameron W. Brennan,Adriana Heguy,Linda M. Liau,Frank Lieberman,W. K. Alfred Yung,Mark R. Gilbert,David A. Reardon,Jan Drappatz,Patrick Y. Wen,Kathleen R. Lamborn,Susan M. Chang,Michael D. Prados,Howard A. Fine,Steve Horvath,Nian Wu,Andrew B. Lassman,Lisa M. DeAngelis,William H. Yong,John G. Kuhn,Paul S. Mischel,Minesh P. Mehta,Timothy F. Cloughesy,Ingo K. Mellinghoff
crossref(2023)
Igor Vivanco,H. Ian Robins,Daniel Rohle,Carl Campos,Christian Grommes,Phioanh Leia Nghiemphu,Sara Kubek,Barbara Oldrini,Milan G. Chheda,Nicolas Yannuzzi,Hui Tao,Shaojun Zhu,Akio Iwanami,Daisuke Kuga,Julie Dang,Alicia Pedraza,Cameron W. Brennan,Adriana Heguy,Linda M. Liau,Frank Lieberman,W. K. Alfred Yung,Mark R. Gilbert,David A. Reardon,Jan Drappatz,Patrick Y. Wen,Kathleen R. Lamborn,Susan M. Chang,Michael D. Prados,Howard A. Fine,Steve Horvath,Nian Wu,Andrew B. Lassman,Lisa M. DeAngelis,William H. Yong,John G. Kuhn,Paul S. Mischel,Minesh P. Mehta,Timothy F. Cloughesy,Ingo K. Mellinghoff
crossref(2023)
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作者统计
#Papers: 61
#Citation: 22830
H-Index: 26
G-Index: 61
Sociability: 6
Diversity: 0
Activity: 1
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