Research Interests HSCs give rise to additional stem cells (self-renewal) and to progenitor cells (differentiation). This fates decision is determined both by cell autonomous programs and by the surrounding microenvironment, or niche. My past work encompasses the study of the intrinsic and extrinsic regulation of HSCs, purification of potent HSCs, analyses of cell differentiation processes, identification of cytokine signalings in hematopoiesis, and the characterization of HSC niches. As a short-range objective, I will seek to establish a world-class research program of stem cell medicine, which will show synergy with cancer sciences. Niche treatment includes manipulation of normal and cancer stem cells and ex vivo stem cell expansion, which will contribute to stem cell transplantation and cancer treatment.