基本信息
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Career Trajectory
Bio
The Blundell Group focuses on structural and computational biology and their applications to drug discovery. The experimental research seeks to understand multicomponent cell-regulatory systems, currently DNA repair through non-homologous end joining. The Group, which has defined the structure of the 4000-amino-acid kinase DNA-PKcs and discovered an important new component PAXX, is currently investigating their interactions using cryo-EM. The Blundell Group has also produced widely used software packages, including Modeller (~11,200 citations) and Fugue (~1,400 citations) for protein modelling, and SDM and mCSM for predicting effects of mutations on protein stability and interactions. The Group now focuses on machine learning as well as databases to underpin drug discovery and to understand cancer and drug resistance. Blundell has developed new approaches to structure-guided and fragment-based drug discovery in Astex Therapeutics, now with breast cancer and urothelial carcinoma drugs on market. In academia, he has targeted Mycobacterium tuberculosis proteins in the Gates HIT-TB consortium, M. leprae for the American Leprosy Mission and M. abscessus for the Cystic Fibrosis Trust.
Research Interests
Papers共 907 篇Author StatisticsCo-AuthorSimilar Experts
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Proteinsno. 1 (2024): 359-371
Angewandte Chemie International Edition (2024)
Aaron Weimann,Adam M. Dinan,Christopher Ruis,Audrey Bernut,Stephane Pont,Karen Brown,Judy Ryan,Lucia Santos,Louise Ellison, Emem Ukor,Arun P. Pandurangan, Sina Krokowski,Tom L. Blundell,Martin Welch,Beth Blane,Kim Judge,Rachel Bousfield,Nicholas Brown,Josephine M. Bryant,Irena Kukavica-Ibrulj,Giordano Rampioni,Livia Leoni,Patrick T. Harrison,Sharon J. Peacock,Nicholas R. Thomson,Jeff Gauthier,Jo L. Fothergill,Roger C. Levesque,Julian Parkhill,R. Andres Floto
SCIENCEno. 6704 (2024)
BIOINFORMATICSno. 7 (2024)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 17 (2024)
Nature Machine Intelligence (2024)
Simon R. Stockwell,Duncan E. Scott,Gerhard Fischer,Estrella Guarino,Timothy P. C. Rooney,Tzu-Shean Feng,Tommaso Moschetti,Rajavel Srinivasan,Esther Alza,Alice Asteian,Claudio Dagostin,Anna Alcaide, Mathieu Rocaboy,Beata Blaszczyk,Alicia Higueruelo,Xuelu Wang,Maxim Rossmann,Trevor R. Perrior,Tom L. Blundell,David R. Spring,Grahame Mckenzie,Chris Abell,John Skidmore,Ashok R. Venkitaraman,Marko Hyvonen
JOURNAL OF MEDICINAL CHEMISTRYno. 17 (2024): 15521-15536
Catherine L. Lawson,Andriy Kryshtafovych,Grigore D. Pintilie,Stephen K. Burley,Jiri Cerny,Vincent B. Chen,Paul Emsley,Alberto Gobbi,Andrzej Joachimiak,Sigrid Noreng,Michael G. Prisant,Randy J. Read,Jane S. Richardson,Alexis L. Rohou,Bohdan Schneider,Benjamin D. Sellers,Chenghua Shao, Elizabeth Sourial,Chris I. Williams,Christopher J. Williams, Ying Yang, Venkat Abbaraju,Pavel V. Afonine,Matthew L. Baker,Paul S. Bond,Tom L. Blundell,Tom Burnley,Arthur Campbell,Renzhi Cao,Jianlin Cheng,Grzegorz Chojnowski,K. D. Cowtan,Frank DiMaio,Reza Esmaeeli,Nabin Giri,Helmut Grubmueller,Soon Wen Hoh,Jie Hou,Corey F. Hryc,Carola Hunte,Maxim Igaev,Agnel P. Joseph,Wei-Chun Kao,Daisuke Kihara,Dilip Kumar,Lijun Lang, Sean Lin,Sai R. Maddhuri Venkata Subramaniya,Sumit Mittal,Arup Mondal,Nigel W. Moriarty,Andrew Muenks,Garib N. Murshudov,Robert A. Nicholls,Mateusz Olek,Colin M. Palmer,Alberto Perez,Emmi Pohjolainen,Karunakar R. Pothula,Christopher N. Rowley,Daipayan Sarkar,Luisa U. Schaefer,Christopher J. Schlicksup,Gunnar F. Schroeder,Mrinal Shekhar,Dong Si,Abhishek Singharoy,Oleg V. Sobolev,Genki Terashi,Andrea C. Vaiana,Sundeep C. Vedithi,Jacob Verburgt,Xiao Wang,Rangana Warshamanage,Martyn D. Winn,Simone Weyand,Keitaro Yamashita,Minglei Zhao,Michael F. Schmid,Helen M. Berman,Wah Chiu
NATURE METHODSno. 7 (2024)
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Author Statistics
#Papers: 907
#Citation: 58873
H-Index: 122
G-Index: 221
Sociability: 8
Diversity: 4
Activity: 235
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