Thomas W. Harrity

From the Department of Experimental Pathology The Squibb Institute for Medical Research

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论文共 47 篇作者统计合作学者相似作者

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Discovery of Clinical Candidate BMS-823778 as a Potent Inhibitor of Human 11beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD-1)

Jun Li,Lawrence J. Kennedy,Steven J Walker,Haixia Wang,James J Li,Zhenqiu Hong,Stephen P O'Connor,Xiang-Yang Ye,Stephanie Y Chen,Shung Wu,David S Yoon,Akbar Nayeem,Daniel M Camac,Vidhyashankar Ramamurthy,Paul E Morin,Steven Sheriff,Mengmeng Wang,Timothy M. Harper,Rajasree Golla,Ramakrishna Seethala,Thomas W Harrity,Randolph P. Ponticiello,Nathan N. Morgan,Joseph R. Taylor,Rachel Zebo,Brad D. Maxwell,Frederick Moulin,David A. Gordon,Jeffrey A Robl

ACS Medicinal Chemistry Letters（2018）

引用0浏览0引用

Discovery of Clinical Candidate BMS-823778 As an Inhibitor of Human 11Β-Hydroxysteroid Dehydrogenase Type 1 (11Β-Hsd-1)

Jun Li,Lawrence J. Kennedy,Steven J. Walker,Haixia Wang,James J. Li,Zhenqiu Hong,Stephen P. O'Connor,Xiang-yang Ye,Stephanie Chen,Shung Wu,David S. Yoon,Akbar Nayeem,Daniel M. Camac,Vidhyashankar Ramamurthy,Paul E. Morin,Steven Sheriff,Mengmeng Wang,Timothy W. Harper,Rajasree Golla,Ramakrishna Seethala,Thomas Harrity,Randolph P. Ponticiello,Nathan N. Morgan,Joseph R. Taylor,Rachel Zebo,Brad Maxwell,Frederick Moulin,David A. Gordon,Jeffrey A. Robl

ACS medicinal chemistry letters（2018）

引用2浏览0WOS引用

PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor

Jon J. Hangeland,Lynn M. Abell,Leonard P. Adam,Ji Jiang,Todd J. Friends,Lauren E. Hague,James Neels,Joelle M. Onorato,Alice Ye A. Chen,David S. Taylor,Xiaohong Yin,Thomas W. Harrity,Michael D. Basso,Richard Yang,Paul G. Sleph,David A. Gordon,Christine S. Huang,Ruth R. Wexler,Heather J. Finlay,R. Michael Lawrence

ACS medicinal chemistry letters（2018）

引用9浏览0WOS引用

Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor

Xiang-Yang Ye,Stephanie Y Chen,Shung Wu,David S Yoon,Haixia Wang,Zhenqiu Hong,Stephen P O'Connor,Jun Li,James J Li,Lawrence J Kennedy,Steven J Walker,Akbar Nayeem,Steven Sheriff,Daniel M Camac,Vidyhashankar Ramamurthy,Paul E Morin,Rachel Zebo,Joseph R Taylor,Nathan N Morgan,Randolph P Ponticiello,Thomas Harrity,Atsu Apedo,Rajasree Golla,Ramakrishna Seethala,Mengmeng Wang,Timothy W Harper,Bogdan G Sleczka,Bin He,Mark Kirby,David K Leahy,Jianqing Li,Ronald L Hanson,Zhiwei Guo,Yi-Xin Li, John D DiMarco, Raymond Scaringe,Brad Maxwell,Frederick Moulin,Joel C Barrish,David A Gordon,Jeffrey A Robl

JOURNAL OF MEDICINAL CHEMISTRY（2017）

引用11浏览0WOS引用

Discovery And Preclinical Evaluation Of Bms-711939, An Oxybenzylglycine Based Ppar Alpha Selective Agonist

Yan Shi,Jun Li,Lawrence J. Kennedy,Shiwei Tao,Andres S. Hernandez,Zhi Lai,Sean Chen,Henry Wong,Juliang Zhu,Ashok Trehan,Ngiap-Kie Lim,Huiping Zhang,Bang-Chi Chen,Kenneth T. Locke,Kevin M. O'Malley,Litao Zhang,Rai Ajit Srivastava,Bowman Miao,Daniel S. Meyers,Hossain Monshizadegan,Debra Search,Denise Grimm,Rongan Zhang,Thomas Harrity,Lori K. Kunselman,Michael Cap,Jodi Muckelbauer,Chiehying Chang,Stanley R. Krystek,Yi-Xin Li,Vinayak Hosagrahara,Lisa Zhang,Pathanjali Kadiyala,Carrie Xu,Michael A. Blanar,Robert Zahler,Ranjan Mukherjee,Peter T. W. Cheng,Joseph A. Tino

ACS medicinal chemistry letters（2016）

引用5浏览0WOS引用

Optimization Of 1,2,4-Triazolopyridines As Inhibitors Of Human 11 Beta-Hydroxysteroid Dehydrogenase Type 1 (11 Beta-Hsd-1): Discovery Of Clinical Candidate Bms-823778

Jun Li,Lawrence Kennedy,Haixia Wang, James Li,Steven Walker,Zhenqiu Hong,Stephen O'Connor,Xiang-Yang Ye,Stephanie Chen,Shung Wu,David Yoon,Akbar Nayeem,Daniel Camac,Paul Morin,Steven Sheriff,Mengmeng Wang,Tim Harper,Rajasree Golla,Ramakrishna Seethala,Thomas Harrity,Randolph Ponticiello,Nathan Morgan,Joseph Taylor,Rachel Zebo,David Gordon,Jeffrey Robl

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY（2015）

引用0浏览0引用

Discovery Of The Clinical Candidate Bms-816336, An Adamantyl Acetamide Based 11 Beta-Hydroxysteroid Dehydrogenase Type-1 (11 Beta-Hsd1) Inhibitor

Xiang-Yang Ye,Stephanie Chen,Shung Wu,David Yoon,Haixia Wang, Zhengqiu Hong, Stephen Oconnor,James Li,Jun Li,Steven Walker,Lawrence Kennedy,Atsu Apedo,Akbar Nayeem,Steven Sheriff,Paul Morin,Daniel Camac,Thomas Harrity,Rachel Zebo,Joseph Taylor,Nathan Morgan,Randolph Ponticiello,Rajasree Golla,Ramakrishna Seethala,Mengmeng Wang,Timothy Harper,Bogdan Sleczka,Bin He,Mark Kirby,John Dimarco, Raymond Scaringe,Ronald Hanson,Zhiwei Guo,Jianqing Li,Jung-Hui Sun,Michael Wong,Bang-Chi Chen,Lauren Haque,David Leahy,Collin Chan,Yi-Xin Li,Tatyana Zvyaga,Lars Hansen, Chirag Patel,David Gordon,Jeffrey Robl

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY（2015）

引用0浏览0引用

Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists

Hao Zhang,Charles Z Ding,Zhi Lai,Sean S Chen,Pratik Devasthale,Tim Herpin,George Morton,Fucheng Qu,Denis Ryono,Rebecca Smirk,Wei Wang,Shung Wu,Xiang-Xang Ye,Yi-Xin Li,Atsu Apedo,Dennis Farrelly,Tao Wang,Liqun Gu,Nathan Morgan,Neil Flynn,Cuixia Chu,Lori Kunselman,Jonathan Lippy,Kenneth Locke,Kevin O'Malley,Thomas Harrity,Michael Cap,Lisa Zhang,Vinayak Hosagrahara,Pathanjali Kadiyala,Carrie Xu,Arthur M Doweyko,Robert Zahler,Narayanan Hariharan,Peter T W Cheng

Bioorganic & Medicinal Chemistry Letters（2015）

引用12浏览0WOS引用

Optimization of 1,2,4-Triazolopyridines As Inhibitors of Human 11Β-Hydroxysteroid Dehydrogenase Type 1 (11Β-Hsd-1)

Jun Li,Lawrence J Kennedy,Haixia Wang,James J Li,Steven J Walker,Zhenqiu Hong,Stephen P O'Connor,Akbar Nayeem,Daniel M Camac,Paul E Morin,Steven Sheriff,Mengmeng Wang,Timothy Harper,Rajasree Golla,Ramakrishna Seethala,Thomas Harrity,Randolph P Ponticiello,Nathan N Morgan,Joseph R Taylor,Rachel Zebo,David A Gordon,Jeffrey A Robl

ACS medicinal chemistry letters（2014）

引用26浏览0WOS引用

11Β-Hydroxysteroid Dehydrogenase Type 1 Gene Knockout Attenuates Atherosclerosis and in Vivo Foam Cell Formation in Hyperlipidemic Apoe−/− Mice

Ricardo A. Garcia,Debra J. Search,John A. Lupisella,Jacek Ostrowski,Bo Guan,Jian Chen,Wen-Pin Yang,Amy Truong,Aiqing He,Rongan Zhang,Mujing Yan,Samuel E. Hellings,Peter S. Gargalovic,Carol S. Ryan,Linda M. Watson,Robert A. Langish,Petia A. Shipkova,Nancy L. Carson,Joseph R. Taylor,Richard Yang,George C. Psaltis,Thomas W. Harrity,Jeffrey A. Robl,David A. Gordon

PLoS ONE（2013）

引用31浏览0WOS引用

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作者统计

#Papers: 47

#Citation: 1510

H-Index: 22

G-Index: 35

Sociability: 6

Diversity: 2

Activity: 0

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