Thomas Hollin

Malaria remains one of the deadliest infectious diseases in the world whose Plasmodium falciparum is the most virulent form. Despite the progress achieved in the past years, the spread of resistance to antimalarial drugs and the lack of effective vaccine make malaria still remains a severe public health problem worldwide. A major obstacle in the development of novel antimalarials is our limited knowledge of basic parasite biology and the paucity of new therapeutic targets/strategies. In Plasmodium, mechanisms controlling gene expression at the (post-)transcriptional and (post-)translational levels possess many atypical characteristics and are still poorly understood. Using genomic and proteomic approaches, we expect to elucidate critical regulatory networks of Plasmodium falciparum.