My major interest is in elucidating mechanisms of injury in glomerulonephritis. We have used a number of models of induced and autoimmune glomerulonephritis to explore the role of macrophages, antibodies, Fc receptors, complement and other mediators. We have also studied genetic influences on susceptibility to glomerulonephritis and to autoimmunity. We are currently investigating the genes that control macrophage activation and the contribution of these to crescentic glomerulonephritis.
I have a major interest in how histological features in human renal biopsies can be used to predict outcome and response to treatment. I have organised international collaborative studies to develop consensus classifications of lupus glomerulonephritis, IgA nephropathy and diabetic nephropathy. We are currently studying the predictive value of transcript analysis in biopsies of transplant kidneys.