Dr. Siddique has been at the forefront of ALS research for 36 years. In fact, he and his collaborators discovered the first cause of ALS, linking mutations in the SOD1 gene to the disease, and developed the first animal models for ALS and ALS/dementia, now used by investigators all over the world. Over the years, Dr. Siddique’s research has pioneered additional causes and signatures for both familial and sporadic forms of the disease and paved the way for targeted treatments.