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职业迁徙
个人简介
I am researcher with over 10 years experience and interest in uncovering cellular and molecular pathogenesis of renal pathologies as well as rare genetic diseases. I am proficient in a wide variety of cell and molecular biology techniques, zebrafish and mice models of disease, and next generation sequencing (NGS) technologies including genome/exome sequencing as well as bulk RNA-Sequencing.
I currently work as a postdoctoral scientist in the Wilson Lab at the Steve and Cindy Rasmussen Institute for Genomic Medicine at the Nationwide Children's Hospital Columbus OH. Here, under the mentorship of Dr. Rick Wilson, I work on a variety of translational protocols that serve to identify the genetic underpinnings of rare pediatric syndromes, pediatric refractory epilepsy, and other developmental and neuropsychiatric conditions. To this end, we use next generation sequencing techniques including whole genome/exome sequencing, RNA sequencing as well as functional studies to identify rare disease-causing variants.
Previously, as a graduate student at the Aguilar Lab in Purdue University, West Lafayette IN, I worked on uncovering novel cellular phenotypes in Lowe Syndrome (LS), a rare congenital X-linked disorder and their underlying mechanisms, as well as identified FDA-approved drugs that could ameliorate these phenotypes, thereby identifying the first ever potential therapeutics for this lethal condition. Given that patients experience seizures and often succumbed to disease due to renal failure , we identified those cellular phenotypes with a specific relevance to renal as well as neuronal physiology. This disease is caused by mutations in OCRL1 gene, over 200 of which have been found to cause LS. There is extensive support for heterogeneity in the clinical presentation of LS amongst patients, but this cause for this is unclear. As part of my graduate work, using cellular and a zebrafish models of LS, I also uncovered OCRL1 genotype- cellular phenotype relationship relevant to LS, that may provide the first level of explanation for why we see diverse clinical presentations amongst LS patients. This may further allow clinicians to better tailor therapeutic strategies for these children. These studies have provided the foundation for collaborations with Riley Children's Hospital, IN to perform pre-clinical studies in LS patient cohorts.
Prior to graduate school, I served as a research intern/assistant in the Bonventre Lab at the Brigham and Women's Hospital, Boston MA under the mentorship of Dr. Venkata Sabbisetti. Here, I was involved in determining the role of Kidney Injury Molecule-1 (KIM-1) in Renal and Ovarian Cell Carcinoma. Previous studies have demonstrated high levels of plasma KIM-1 in patients with renal and ovarian cell carcinoma. My findings indicated that knockdown of KIM-1 in renal cancer cell lines induced G1/S cell cycle arrest as well as senescence. Further, loss of KIM-1 induced DNA damage response suggesting a likely oncogenic role for KIM-1 in renal cell carcinoma. These findings taken together with recent publication from the lab showing a correlation of KIM-1 levels and metastasis suggest a potential oncogenic role for KIM-1 in renal cell carcinoma. This provides a likely foundation for using KIM-1 as a potential target for combating renal cell carcinoma. To this end, I was also involved in generation and use of anti-KIM1 targeted immunoliposomes (carrying therapeutic loads) in renal cancer cells to determine their ability to induce tumor growth reduction in cell culture models. Further, I also investigated the role of KIm-1 in chronic kidney disease and acute kidney injury using cell culture and mice models of kidney disease.
During my undergraduate degree, I won a Summer Research Fellowship (conferred by the Indian Academy of Sciences) to Dr. Ashwin Dalal's lab (diagnostics division) at the Center for DNA Fingerprinting and Diagnostics) where I was trained on sample preparation, G-banding karyotyping of de-identified patient samples in who a chromosomal genetic condition was suspected; to determine any potential medically meaningful chromosomal aberrations that could explain their condition.
研究兴趣
论文共 29 篇作者统计合作学者相似作者
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Swetha Ramadesikan, Caitlyn Colwell,Mohammad Marhabaie, Leeran Dublin-Ryan,Iftekhar Showpnil, Umamaheswaran Gurusamy,Jesse Hunter, Allison Daley,Elizabeth Varga,Marco Leung,Rolf Stottmann,Bimal Chaudhari,Scott Hickey,Peter White,Daniel Koboldt,Richard Wilson
Genetics in Medicine Open (2024): 101080
Umamaheswaran Gurusamy,Swetha Ramadesikan,Mohammad Marhabaie, Caitlyn M. Colwell,Jesse M. Hunter,Marco L. Leung,Elaine R. Mardis,Peter White, Murugu Manickam,Richard K. Wilson,Daniel C. Koboldt
FRONTIERS IN GENETICS (2024)
Jennifer Lee,Swati Mundre, Andres Pacheco,Swetha Ramadesikan, Adrianna Black,Lisette Skiba,Ruben Aguilar
Journal of Biological Chemistry (2023)
D. Thomas,K. Schieffer, O. Singh,S. Ramadesikan, M. Lazow, D. Pratt,Z. Abdullaev, M. Deng, D. Jones,F. Sahm,M. Quezado, C. Ketchum, D. Marker, S. Kulich,C. Pierson,D. Boue,M. Fouladi, J. Leonard,C. Cottrell,K. Aldape
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGYno. 6 (2023): 495-495
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MOLECULAR BIOLOGY OF THE CELLno. 2 (2023): 996-996
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MOLECULAR BIOLOGY OF THE CELLno. 2 (2023): 1132-1133
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Swetha Ramadesikan, Caitlyn M. Colwell, Rachel Supinger,Jesse Hunter,Jessica Thomas,Elizabeth Varga,Elaine R. Mardis,Richard J. Wood,Daniel C. Koboldt
NEURO-ONCOLOGY (2023)
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#Papers: 29
#Citation: 455
H-Index: 8
G-Index: 10
Sociability: 5
Diversity: 2
Activity: 6
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