Susana Proenca - Institute for Risk Assessment Sciences, Utrecht University

基本信息

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职业迁徙

个人简介

I am interest in establishing frameworks for extrapolating in vitro ADME or effect concentration to in vivo real scenarios with the use of PBK modelling.

研究兴趣

论文共 23 篇作者统计合作学者相似作者

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S15-02 Biokinetic Frameworks for Hazard Characterization

S. Proença,R. Geci, S. Adam,N. Kramer, S. Schaller

Toxicology Letters (2024): S31

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P05-43 What Does It Take to Make a PBK for a Pesticide in a NGRA Framework? Evaluation of the Kinetic Space of Pesticides and How to Model It Using Open-Source Tools

S. Proença,S. Fragki, L. Lamon,L. Lautz, M. Siccardi

Toxicology Letters (2024): S148

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OS03-06 Aggregated Exposure to Perfluorooctane Sulfonic Acid Coupled with PBPK Model and Parameter Optimization Using a Human Study for Validation

M. Kalyva,M.W. Wojewodzic, H. Personen, A. Rand, H. Keegan,H.K. Knutsen,L.S. Haug,S. Proença,R. Geci, C. Thomsen,H. Dirven, T. Hus⊘y

Toxicology Letters (2024): S65

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P03-06 Distribution Kinetics of Azole Fungicides in an in Vitro Liver Steatosis Model

S. Adam, M. Anagnostaki, W. Bakker, A. Sotiriou,S. Proença, A. Verhoeven,M. Vinken,N. Kramer

Toxicology Letters (2024): S124-S125

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The Effects of Hexabromocyclododecane on the Transcriptome and Hepatic Enzyme Activity in Three Human HepaRG-based Models

Susana Proenca, Nick van Sabben,Juliette Legler,Jorke H. Kamstra,Nynke I. Kramer

Toxicology（2023）

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Integrating distribution kinetics and toxicodynamics to assess repeat dose neurotoxicity in vitro using human BrainSpheres: a case study on amiodarone

Carolina Nunes,Susana Proença,Giovanna Ambrosini,David Pamies,Aurélien Thomas,Nynke I Kramer,Marie-Gabrielle Zurich

Frontiers in pharmacology (2023): 1248882

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OS04-02: Next Generation PBK Modeling with PK-Sim for the Prediction of Chemical Distribution in Humans

R. Geci,D. Gadaleta,S. Proenca, E. Colombo, M. Garcia de Lomana, R. Ortega Vallbona,N. Kramer,A. Paini,L. Kuepfer,S. Schaller

TOXICOLOGY LETTERS (2023): S70-S71

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Drug Metabolism of Hepatocyte-like Organoids and Their Applicability in in Vitro Toxicity Testing

Manon C. Bouwmeester, Yu Tao,Susana Proenca,Frank G. van Steenbeek,Roos-Anne Samsom,Sandra M. Nijmeijer,Theo Sinnige,Luc J. W. van der Laan,Juliette Legler,Kerstin Schneeberger,Nynke I. Kramer,Bart Spee

Molecules（2023）

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S23-03: A Qualified Open-Source Framework for Precision Toxicology by Integration of PBK with Mechanism-Based Quantification of AOPs

S. Schaller,A. Paini,P. Balazki,R. Geci,S. Proenca,N. Kramer,L. Kuepfer,H. Yang

TOXICOLOGY LETTERS (2023): S48-S48

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