Dr. Witte’s research is broadly targeted to the evolution of more efficient and effective methods for evidence-based program implementation in local and global communities. She collaborated with SIG investigators to develop and promote couple-based interventions for heterosexual women beginning in 1997 and has tested, packaged, and disseminated the first of these, the Connect intervention, also a CDC DEBI. She led one of the largest HIV/STI dissemination projects to date, testing the adoption and effectiveness of a multimedia couple-based HIV prevention program delivered in HIV services agencies across New York State. Her past and ongoing research has been funded by NIMH, NIAAA, NIDA, and CDC.

Dr. Witte has also worked since 1995 with communities of women engaged in sex work. She collaborates with colleagues in the United States and abroad, predominantly in Mongolia and currently in Kazakhstan, to test the benefit of adding financial literacy, business development, and microsavings components to HIV prevention for women in sex work.