Wallace’s research has provided a much greater understanding of the mechanisms at play in the development of cancer and how radiation affects the genome. This work has attracted millions of dollars in research support – consistent National Institutes of Health funding since 1971, including two prestigious MERIT awards and a Program Project grant award to support translational research exploring a potential link between certain DNA repair protein variants in the human population and an increase the risk for some types of cancer. In addition, she has published more than 200 biomedical journal articles and trained many successful graduate students and postdoctoral fellows at UVM.