My interest is to extend metabolic health by understanding precise and patient-specific drivers of molecular processes leading to dysfunctional in diverse tissues in the body, and to diseases including obesity, diabetes, steatohepatitis, and atherosclerosis. We use a variety of approaches to identify specific cell types and pathways that are essential for maintaining optimal metabolic health. Current projects focus on myeloid cells, including microglia and other tissue-specialized myeloid populations, adipocytes and their precursors, and other parenchymal cell types that underlie tissue function, including hypothalamic neurons and hepatocytes. Our projects focus on cells, animal models, and deeply characterized human cohorts.