Research interests
Dr. Wong's research focuses on understanding health and disease from a systems perspective in order to generate cost-effective strategies and solutions for disease management. His research approaches combine both experimental and high throughput biology with rigorous computational, bioinformatics, biophysics, and imaging methods to achieve a deep understanding of the functions of each component in biological systems and integration of them with multilevel systems analysis. For example, the consequences of genetic variation, cell-cell interactions and environmental factors are included to reflect the circumstances and microenvironments of the disease condition. Current research projects include pathway modeling and high throughput phenotyping approaches for target discovery and drug repurposing in combating neurological disorders and cancer, and for understanding the mechanisms of these diseases. Additional projects include reformulation of small molecule drugs using chemical biology approaches, the development of point-of-care molecular diagnosis and monitoring devices using biophotonics and nanotechnology techniques, and the development of label-free molecular image-guided cancer therapy platforms.