He has a long-standing interest in the aetiology and pathophysiology of human metabolic and endocrine disease and how such information might be used to improve diagnosis, prognostication, therapy and prevention. He is the Principal Investigator on an MRC Programme Grant focused on Molecular and Pathophysiological Mechanisms in Obesity and also on a Wellcome Trust Programme Grant focused on Mechanisms of Human Insulin Resistance.

He has won many awards for his work including the Society for Endocrinology Medal, the European Journal of Endocrinology Prize, the Novartis International Award for Clinical Research in Diabetes, the Heinrich Wieland Prize, the Rolf Luft Award, the Feldberg Prize, the Society for Endocrinology Dale Medal and the InBev Baillet-Latour Prize for Health.