The Department of Developmental Genetics investigates questions related to organogenesis including cell differentiation, tissue morphogenesis, organ homeostasis and function, as well as organ regeneration. We study these questions in zebrafish as well as in mouse and are currently looking at several mesodermal (heart, vasculature) and endodermal (lung) organs. We utilize both forward and reverse genetic approaches, and aim to dissect cellular processes using high-resolution live imaging. One goal of our studies is to gain an understanding of vertebrate organ development and regeneration at the single-cell level. Another goal is to decipher mechanisms of transcriptional adaptation and genetic compensation using a variety of model systems.