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个人简介
Dr. Saladi’s research interests primarily focus on understanding the mechanism by which epigenetic reprogramming contributes to cellular plasticity in tumors. His research aims to define the mechanisms in which deregulated chromatin remodeling or altered chromatin landscape act as oncogenic drivers in cancer. Epigenetic reprogramming is a key oncogenic driver event in multiple cancers, however very little is known about the deregulated epigenetic programs in head and neck squamous cell carcinomas (HNSCC).
His research interests also include delineating the oncogenic role of hippo signaling pathway effector, YAP1 in squamous cell carcinomas. Hippo pathway was shown to bypass the MAPK oncogenic addiction in advanced stage of multiple cancers contributing to cancer progression. Dr. Saladi has unraveled the oncogenic role of Hippo pathway in HNSCC. He had identified WWC1 and GPRC5A (upstream inhibitors of oncogenic YAP1 activity) as repressed in HNSCC, thereby promoting tumorigenesis and conferring poor prognosis in a subset of HNSCC patients.
Collectively, Dr. Saladi integrates genomics, epigenetics, and signaling to dissect the mechanisms contributing to head and neck cancer maintenance and progression.
His research interests also include delineating the oncogenic role of hippo signaling pathway effector, YAP1 in squamous cell carcinomas. Hippo pathway was shown to bypass the MAPK oncogenic addiction in advanced stage of multiple cancers contributing to cancer progression. Dr. Saladi has unraveled the oncogenic role of Hippo pathway in HNSCC. He had identified WWC1 and GPRC5A (upstream inhibitors of oncogenic YAP1 activity) as repressed in HNSCC, thereby promoting tumorigenesis and conferring poor prognosis in a subset of HNSCC patients.
Collectively, Dr. Saladi integrates genomics, epigenetics, and signaling to dissect the mechanisms contributing to head and neck cancer maintenance and progression.
研究兴趣
论文共 52 篇作者统计合作学者相似作者
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Jong Chul Park,Nandini Pal Basak, Mateo Useche,Jun Seok Park, Mandakulutur Subramanya Ganesh,Amritha Prabha, Chandra Reddy JayaPrakash,Mark Varvares,Lori Wirth,William Faquin,Satish Sankaran,Srinivas Vinod Saladi
biorxiv(2024)
crossref(2024)
Kunal Rai,Mayinuer Maitituoheti,Alvin Shi,Ming Tang,Li-Lun Ho,Firas Youssef Kreidieh,Christopher Terranova,Kyriakitsa Galani,Emily Z. Keung,Caitlin A. Creasy,Manrong Wu,Jiajia Chen,Nana Chen,Anand K. Singh,Apoorvi Chaudhri,Nazanin E. Anvar, Giuseppe Tarrantino,Jiekun Yang,Sharmistha Sarkar,Shan Jiang,Jared Malke,Lauren Haydu,Elizabeth Burton,Michael A. Davies,Jeffrey E. Gershenwald,Patrick Hwu,Alexander Lazar,Jaime H. Cheah,Christian K. Soule,Stuart S. Levine,Chantale Bernatchez,Srinivas V. Saladi,David Liu,Hussein Tawbi,Jennifer Wargo,Genevieve M. Boland,Manolis Kellis
CANCER RESEARCHno. 7 (2023)
Avinash Waghray, Isha Monga,Brian Lin,Viral Shah,Michal Slyper,Bruno Giotti,Jiajie Xu,Julia Waldman,Danielle Dionne,Lan T. Nguyen, Wendy Lou,Peiwen Cai, Eric Park,Christoph Muus,Jiawei Sun,Manalee V Surve, Lujia Cha Cha Yang,Orit Rozenblatt-Rosen, Toni M Dolerey,Srinivas Vinod Saladi,Alexander M Tsankov,Aviv Regev,Jayaraj Rajagopal
bioRxiv the preprint server for biology (2023)
Karina J. Matissek,Maristela L. Onozato, Shuhui Sun,Zongli Zheng,Andrew J. Schultz,Vivian Lee, Kristofer Patel,Piiha-Lotta Jerevall,Srinivas Vinod Saladi,Allison Macleay,Mehrad Tavallai,Tanja Badovinac-Črnjević, Carlos H. Barrios,Nuran Beşe, Arlene Chan,Yanin Chávarri-Guerra,Márcio Debiasi,Elif Demirdögen,Ünal Egelí,Sahsuvar Gökgöz,Henry Gómez,Pedro Emanuel Rubini Liedke,İsmet Taşdelen,Şahsine Tolunay,Gustavo Werutsky,Jessica St. Louis,Nora Horick,Dianne M. Finkelstein,Long P. Le,Aditya Bardia, Paul E. Goss,Dennis C. Sgroi,A. John Iafrate,Leif W. Ellisen
openalex
David Li‐Kroeger,Ismael Al‐Ramahi, Nathaniel Smith, Aditi Marella,Bismark K Amoh,Srinivas Vinod Saladi,Juan Botas,Nicholas T. Seyfried,Allan I. Levey,Zhandong Liu
Alzheimer's & dementiano. S12 (2023)
Cell death and diseaseno. 11 (2023)
Kunal Rai,Mayinuer Maitituoheti,Alvin Shi,Ming Tang,Li-Lun Ho,Firas Youssef Kreidieh,Christopher Terranova,Kyriakitsa Galani,Emily Z. Keung,Caitlin A. Creasy,Manrong Wu,Jiajia Chen,Nana Chen,Anand K. Singh,Apoorvi Chaudhri,Nazanin E. Anvar, Giuseppe Tarrantino,Jiekun Yang,Sharmistha Sarkar,Shan Jiang,Jared Malke,Lauren Haydu,Elizabeth Burton,Michael A. Davies,Jeffrey E. Gershenwald,Patrick Hwu,Alexander Lazar,Jaime H. Cheah,Christian K. Soule,Stuart S. Levine,Chantale Bernatchez,Srinivas V. Saladi,David Liu,Hussein Tawbi,Jennifer Wargo,Genevieve M. Boland, Manolis Kellis
Cancer Researchno. 7_Supplement (2023): 6425-6425
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作者统计
#Papers: 51
#Citation: 946
H-Index: 13
G-Index: 30
Sociability: 6
Diversity: 0
Activity: 1
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