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Her research focus is on hematopoietic stem cell (HSC) biology and the development of human synthetic leukemia models to identify therapeutic vulnerabilities in high fatality pediatric leukemia. Long-lived HSC sustain the constant production of all mature cell lineages in the blood system, and constitute the critical cellular component of transplantation procedures performed in oncology for high risk malignancies, including leukemia. Nonetheless, factors that dictate HSC fate remain poorly defined, and their isolation and ex vivo culture remain challenging, limiting their clinical applications. The main focus of the laboratory is to study the role of chromatin methylation in human HSC biology. Accessibility of the transcriptional machinery to the genetic code is mediated through the concerted actions of chromatin modifying enzymes. The Mll (Mixed Lineage Leukemia) gene, encoding for a histone methyltransferase (of lysine 4 on histone 3, or H3K4) is involved in normal HSC maintenance and mutated in >70% of infant leukemia cases. Once thought to be irreversible, histone methylation is now regarded as a highly dynamic process, since the identification of the histone demethylase LSD1 (KDM1A) in 2004.
Research Interests
Papers共 109 篇Author StatisticsCo-AuthorSimilar Experts
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Stephanie Bianco, Anas Belaktib,Virgile Raufaste-Cazavieille,Charles Joly-Beauparlant, Lara Herrmann, Emeric Texeraud,Sylvie Langlois,Thomas Sontag, Alex Richard-St-Hilaire,Vincent-Philippe Lavallee,Thai Hoa Tran,Sonia Cellot,Daniel Sinnett, Arnaud Droit,Raoul Santiago
CANCER RESEARCHno. 17 (2024)
Genetics in Medicine Open (2024): 100997
Safia Safa-Tahar-Henni, Karla Páez Martinez, Verena Gress, Nayeli Esparza, Élodie Roques, Florence Bonnet-Magnaval, Mélanie Bilodeau, Valérie Gagné, Eva Bresson, Sophie Cardin, Nehme El-Hachem, Isabella Iasenza, Gabriel Alzial, Isabel Boivin, Naoto Nakamichi, Anne-Cécile Soufflet, Cristina Mirela Pascariu, Jean Duchaine, Simon Mathien, Éric Bonneil,Kolja Eppert,Anne Marinier,Guy Sauvageau, Geneviève Deblois,Pierre Thibault, Josée Hébert, Connie J Eaves,Sonia Cellot, Frédéric Barabé, Brian T Wilhelm
Leukemia (2024)
Verena Gress,Mathieu Roussy,Luc Boulianne,Melanie Bilodeau, Sophie Cardin, Nehme El-Hachem,Veronique Lisi, Banafsheh Khakipoor,Alexandre Rouette,Azer Farah,Louis Theret,Leo Aubert,Furat Fatima,Eric Audemard,Pierre Thibault,Eric Bonneil, Jalila Chagraoui,Louise Laramee,Patrick Gendron,Loubna Jouan, Safa Jammali,Bastien Pare, Shawn M. Simpson,Thai Hoa Tran,Michel Duval,Pierre Teira, Henrique Bittencourt, Raoul Santiago, Frederic Barab,Guy Sauvageau, Martin A. Smith, Josee Hebert,Philippe P. Roux,Tanja A. Gruber, Vincent -Philippe Lavallee,Brian T. Wilhelm,Sonia Cellot
BLOOD ADVANCESno. 1 (2024): 112-129
Antoine Gourmel, Heloise Perrault,Marie-Laure Colaiacovo,Louise Laramee,Marieke Rozendaal,Henrique Bittencourt,Caroline Laverdiere,Josette Champagne,Sonia Cellot,Lewis B. Silverman,Emmanuelle Lemyre,Catalina Maftei,Geraldine Mathonnet,Frederique Tihy,Marie-Claude Pelland-Marcotte,France Leveille,Thai Hoa Tran
Virgile Raufaste-cazavieille,Stéphanie Bianco, Lara Hermann, Jeyani George Clement, Emeric Texeraud,Sylvie Langlois,Thomas Sontag, Pascal Tremblay-Dauphinais, Alex Richard-St-Hilaire,Charles Joly Beauparlant,Loïc Mangnier,Stéphanie Vairy,Sonia Cellot,Vincent-Philippe Lavallee,Thai Hoa Tran,Daniel Sinnett, Arnaud Droit,Raoul Santiago
Cancer Researchno. 17_Supplement (2024)
Gervaise Hubert,Henrique Bittencourt,Caroline Laverdière,Pierre Teira,Sonia Cellot,Sylvie Langlois,Alexandre Rouette,Thomas Sontag,Daniel Sinnett, Dorothée Dal-Soglio,Sophie Turpin,Thai Hoa Tran
Robyn Hebert,Noelle Cullinan,Linlea Armstrong,Katherine A. Blood,Josee Brossard,Ledia Brunga,Chantel Cacciotti,Kimberly Caswell,Sonia Cellot,Hallie Coltin,Rebecca J. Deyell,Kathleen Felton,Conrad V. Fernandez,Adam J. Fleming,Paul Gibson,Rawan Hammad,Nada Jabado,Donna L. Johnston,Lucie Lafay-Cousin,Valerie Larouche,Cassandra Leblanc-Desrochers,Orli Michaeli,Renee Perrier,Meghan Pike,Jemma Say,Ian Schiller,Annie-Kim Toupin,Stephanie Vairy,Kalene van Engelen,Nicolas Waespe,Anita Villani,William D. Foulkes,David Malkin,Lara Reichman,Catherine Goudie
Nikhil Raghuram,Daisuke Hasegawa,Kentaro Nakashima,Syaza Rahman,Evangelia Antoniou,Torjus Skajaa,Pietro Merli,Anupam Verma,Karen R. Rabin,Catherine Aftandilian,Rishi S. Kotecha,Daniel Cheuk,Kirsi Jahnukainen,Alexandra Kolenova,Walentyna Balwierz,Alice Norton,Maureen O'Brien,Sonia Cellot,Ashley Chopek,Nira Arad-Cohen,Bianca Goemans,Marta Rojas-Vasquez,Hany Ariffin,Jack Bartram,E. Anders Kolb,Franco Locatelli,Jan-Henning Klusmann,Henrik Hasle, Bryan Mcguire, Afia Hasnain,Lillian Sung,Johann Hitzler
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Author Statistics
#Papers: 108
#Citation: 1197
H-Index: 20
G-Index: 33
Sociability: 7
Diversity: 3
Activity: 17
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