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Our laboratory works with Toxoplasma gondii, an apicomplexan parasite that infects almost one third of the world population. Toxoplasma also infects animals like cats, dogs and cattle worldwide. The infection with Toxoplasma is lifelong and it can cause encephalitis and cardiogenic shock in immuno-compromised patients. The infection of pregnant women could result in devastating effects for the unborn fetus. The pathologies associated with toxoplasmosis stem from its lytic cycle, characterized by active invasion, replication inside a parasitophorous vacuole and egress from host cells. Host cell entry is an obligatory and parasite-specific process choreographed by a unique set of proteins that are sequentially released from apical organelles termed micronemes, rhoptries and dense granules. Our laboratory is interested in discovering unique metabolic differences in Toxoplasma that could be exploited as targets for chemotherapy. The treatments available for Toxoplasmosis are restricted to only one phase of the disease and they have harmful side effects after continuous use. A constant source of new drugs and potential drug targets is needed to stay ahead of the threat posed by this successful pathogen.
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论文共 190 篇作者统计合作学者相似作者
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Zaid Farooq Pitafi, Melissa Sleda,Silvia N. J. Moreno, S. Mark Tompkins,Benjamin M. Brainard,WenZhan Song
ICCpp.812-817, (2024)
Clara A. Solari, Maria Clara Ortola Martinez,Juan M. Fernandez,Christian Bates,Gerardo Cueto,Maria Pia Valacco,Fabian Morales-Polanco,Silvia Moreno,Silvia Rossi,Mark P. Ashe,Paula Portela
ISCIENCEno. 1 (2024)
bioRxiv the preprint server for biology (2024)
The Journal of biological chemistryno. 3 (2024): 105771-105771
Contact (Thousand Oaks (Ventura County, Calif)) (2023): 25152564231189064-25152564231189064
Jonathan Munera Lopez,Andres Mariano Alonso,Maria Julia Figueras, Ana Maria Saldarriaga Cartagena,Miryam A. Hortua A. Triana,Luis Diambra,Laura Vanagas,Bin Deng,Silvia N. J. Moreno,Sergio Oscar Angel
crossref(2023)
Melissa A. Sleda,Zhu-Hong Li,Ranjan Behera,Baihetiya Baierna,Catherine Li, Jomkwan Jumpathong,Satish R. Malwal,Makoto Kawamukai,Eric Oldfield,Silvia N. J. Moreno
MBIOno. 5 (2022)
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#Papers: 192
#Citation: 5851
H-Index: 44
G-Index: 69
Sociability: 6
Diversity: 0
Activity: 1
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