Professor Sandhu sits on multiple international advisory panels and has been principal investigator on multiple investigator-initiated and practise changing registration studies in melanoma and prostate cancer. She leads clinical, translational and laboratory research in skin cancers and prostate cancer with a major focus on designing and conducting biologically driven clinical trials to translate laboratory findings into new clinical treatments and studying biomarkers of response and resistance to treatment.

Over her career to date, Professor Sandhu has been a recipient of multiple awards to support her research and has published over 218 peer-reviewed research articles including in the following journals: New England Journal of Medicine, Journal of Clinical Oncology, Cancer Cell, Cancer Discovery, Lancet Oncology, Annals of Oncology and others.