Shaf Keshavjee
教授
Department of Surgery
Temerty Faculty of Medicine, University of Toronto;Institute of Biomedical Engineering, Faculty of Applied Science & Engineering, University of Toronto;Toronto General Hospital Research Institute;Cancer Clinical Research Unit, Princess Margaret Cancer Centre;Latner Thoracic Research Laboratories;SickKids Research Institute
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个人简介
My lab focuses on the molecular mechanisms of lung preservation, injury and repair. We developed the Toronto Ex Vivo Lung Perfusion (EVLP) system, which has transformed how the world performs lung transplantation. During EVLP, donor lungs are placed in a sterile and protective dome outside of the body (“ex vivo”) and supplied oxygen, nutrients and other critical components that enable the lung to breathe on its own. During the six hours that a lung can remain physiologically active on EVLP, surgeons can fully assess physiologic quality and make a more informed and objective decision on whether to utilize the lung for transplant. Importantly, the hours during which lungs are on EVLP have also enabled a critical time window in which the team can apply novel, isolated therapies to repair injured donor lungs prior to transplant. To this extent, we are currently developing a number of precision diagnostics and novel repair therapies, including gene therapy and CRISPR-Cas9 applications, that will maximize the potential of EVLP in the transplant clinic.
研究兴趣
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The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantationno. 5 (2024): 797-805
Sahar A. Saddoughi,Ben Dunne, Jose Luis Campo-Canaveral de la Cruz,Philipe Lemaitre, Juan Pablo Diaz Martinez, Tereza Martinu,Laura Donahoe,Marc de Perrot,Andrew F. Pierre,Kazuhiro Yasufuku,Thomas K. Waddell,Cecilia Chaparro,
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERYno. 3 (2024): 861-868
The Journal of Heart and Lung Transplantation (2024)
The Journal of Heart and Lung Transplantation (2024)
Natalia Belousova,Ella Huszti,Qixuan Li,Anastasiia Vasileva,Rasheed Ghany, Ramy Gabarin, Moustapha El Sanharawi,Clement Picard,David Hwang,Liran Levy,Shaf Keshavjee,Chung-Wai Chow,
AMERICAN JOURNAL OF TRANSPLANTATIONno. 1 (2024): 89-103
Kumi Mesaki,Haruchika Yamamoto,Stephen Juvet,Jonathan Yeung,Zehong Guan, Akhi Akhter,Yan Yao, Cameron Dickie, Henna Mangat,Aizhou Wang,Gavin W Wilson,Andrea Mariscal,
Human gene therapy (2024)
Cellsno. 10 (2024): 859
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