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Emergence is the phenomenon by which novel properties arise from interactions of simpler fragments which lack that property at a given level of hierarchical complexity. In chemical systems such as polyfunctional natural products, emergent properties are difficult if not impossible to predict, even when very detailed information about the interacting fragments is available. Efforts to analyze natural products without considering their emergent phenomena typically fail as an approach to identifying the most interesting functional features of these molecules. Therefore, our laboratory is working to formalize a study of emergence in bioactive natural products, with the ultimate goal of connecting the modular, evolved chemical reactivity within a natural product with cellular phenotype. Studies of this nature enrich our understanding of structure, bonding and reactivity in complex settings, motivate advances in synthetic strategy and methodology, and provide a blueprint for the creation of novel molecules with desired, complex properties, with implications for human health.
Emergence is the phenomenon by which novel properties arise from interactions of simpler fragments which lack that property at a given level of hierarchical complexity. In chemical systems such as polyfunctional natural products, emergent properties are difficult if not impossible to predict, even when very detailed information about the interacting fragments is available. Efforts to analyze natural products without considering their emergent phenomena typically fail as an approach to identifying the most interesting functional features of these molecules. Therefore, our laboratory is working to formalize a study of emergence in bioactive natural products, with the ultimate goal of connecting the modular, evolved chemical reactivity within a natural product with cellular phenotype. Studies of this nature enrich our understanding of structure, bonding and reactivity in complex settings, motivate advances in synthetic strategy and methodology, and provide a blueprint for the creation of novel molecules with desired, complex properties, with implications for human health.
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Papers共 148 篇Author StatisticsCo-AuthorSimilar Experts
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Brandon W. Alexander, Noah M. Bartfield, Vaani Gupta,Brandon Q. Mercado,Mark Del Campo,Seth B. Herzon
Scienceno. 6685 (2024): 849-854
Michael W. Dougherty, Ryan M. Hoffmann, Yougant Airan,Raad Z. Gharaibeh,Seth B. Herzon,Ye Yang,Christian Jobin
Gastroenterologyno. 5 (2024): S-253
Journal of the American Chemical Societyno. 27 (2024): 18241-18252
Tetrahedron (2024): 134070-134070
Maria Altshuller, Xu He, Elliot J. MacKrell,Kevin M. Wernke,Joel W. H. Wong,Selene Sellés-Baiget,Ting-Yu Wang,Tsui-Fen Chou,Julien P. Duxin,Emily P. Balskus,Seth B. Herzon,Daniel R. Semlow
bioRxiv (Cold Spring Harbor Laboratory) (2024)
Bruce Ruggeri, Kyle Tarantino,Ranjini Sundaram,Kingson Lin,Seth Herzon,Joseph Park, Spenser Johnson,Susan Gueble,Ranjit S. Bindra
CANCER RESEARCHno. 7 (2023)
Organic lettersno. 20 (2023): 3723-3727
Neoplasia (2023): 100918-100918
CANCER RESEARCHno. 7 (2023)
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Author Statistics
#Papers: 133
#Citation: 3137
H-Index: 33
G-Index: 52
Sociability: 5
Diversity: 3
Activity: 107
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