Sebastian Amigorena’s main scientific interest overlaps immunology and cell biology. In his graduate and post-doctoral studies, he analyzed the functions of IgG receptors and described the molecular basis of their inhibitory properties. Sebastian Amigorena is today an expert in antigen presentation and cross presentation in dendritic cells. He analyzed dendritic cells’ endocytic and phagocytic pathways and described several unique specializations of both pathways. Sebastian Amigorena and his team also made significant contributions to the analysis of cytotoxic T cells dynamics in vivo, during the initiation of immune responses in lymph nodes and during the invasion and rejection of solid tumors. More recently, he has contributed to understanding the epigenetic programing of T cell memory. Today, the team studies transposable elements, the regulation of their expression and their roles in anti-tumor immunity.