基本信息
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Career Trajectory
Bio
We are interested in deciphering the evolutionary history of life by comparative analysis of genome sequences. Our research currently focuses on the development of computational methods for RNA, protein, and genome sequence analysis. We use probabilistic modeling approaches to build statistical models of interesting biological features, and use such models for Bayesian or likelihood-based statistical inference in large scale genome analysis and annotation.
We are currently working in three general areas. One area is RNA structure and function. We are developing new methods for RNA homology detection, RNA structure prediction, and identification of conserved RNA structures by comparative genome sequence analysis (including both noncoding RNA genes and cis-regulatory RNA structures). A second area is the improvement of methods for remote protein homology detection, implemented in our HMMER software package. Finally, more recently we have begun collaborating with neuroscientists on the analysis of neural cell-type-specific genomic data, aiming to learn more about the evolution and development specification of neuronal cell types.
We are currently working in three general areas. One area is RNA structure and function. We are developing new methods for RNA homology detection, RNA structure prediction, and identification of conserved RNA structures by comparative genome sequence analysis (including both noncoding RNA genes and cis-regulatory RNA structures). A second area is the improvement of methods for remote protein homology detection, implemented in our HMMER software package. Finally, more recently we have begun collaborating with neuroscientists on the analysis of neural cell-type-specific genomic data, aiming to learn more about the evolution and development specification of neuronal cell types.
Research Interests
Papers共 318 篇Author StatisticsCo-AuthorSimilar Experts
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NATUREno. 8007 (2024): 271-273
Nature communicationsno. 1 (2024)
Anna Reznichenko,Viji Nair,Sean Eddy,Damian Fermin,Mark Tomilo,Timothy Slidel,Wenjun Ju, Ian Henry,Shawn S. Badal,Johnna D. Wesley,John T. Liles,Sven Moosmang,Julie M. Williams,Carol Moreno Quinn,Markus Bitzer,Jeffrey B. Hodgin,Laura Barisoni,Anil Karihaloo,Matthew D. Breyer,Kevin L. Duffin, Uptal D. Patel, Maria Chiara Magnone, Ratan Bhat, Matthias Kretzler
Jonathan P. Troost, Jennifer D'Souza,Miatta Buxton,Abhijit V. Kshirsagar,Lawrence S. Engel, Cassandra R. O'Lenick,William E. Smoyer,Jon Klein,Wenjun Ju,Sean Eddy,Margaret Helmuth,Laura H. Mariani,Matthias Kretzler,Howard Trachtman
KIDNEY INTERNATIONAL REPORTSno. 8 (2024): 2527-2536
Joonho Yoon,Zhenan Liu, Mathew Alaba,Leslie A Bruggeman,Paul Janmey, Carlos Arana, Oluwatoyosi Ayenuyo,Isabela Medeiros,Viji Nair,Sean Eddy,Matthias Kretzler,Joel M Henderson, Abijit Naik,Audrey N Chang,R Tyler Miller
bioRxiv : the preprint server for biology (2024)
Howard Trachtman,Hailey Desmond, Amanda L. Williams,Laura H. Mariani,Sean Eddy,Wenjun Ju,Laura Barisoni,Heather K. Ascani,Wendy R. Uhlmann,Cathie Spino,Lawrence B. Holzman,John R. Sedor,Crystal Gadegbeku,Lalita Subramanian,Chrysta C. Lienczewski, Tina Manieri,Scott J. Roberts,Debbie S. Gipson,Matthias Kretzler
Kidney Internationalno. 2 (2024): 218-230
biorxiv(2024)
bioRxiv the preprint server for biology (2024)
Adam Tisch, Siddharth Madapoosi, Stephen Blough, Jan Rosa,Sean Eddy, Laura Mariani,Abhijit Naik,Christine Limonte, Philip McCown,Rajasree Menon,Sylvia E. Rosas,Chirag R. Parikh,Matthias Kretzler, Ahmed Mahfouz, Fadhl Alakwaa
Heliyon (2024)
Cell reportsno. 6 (2024): 114310-114310
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Author Statistics
#Papers: 318
#Citation: 98708
H-Index: 91
G-Index: 314
Sociability: 8
Diversity: 0
Activity: 2
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