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职业迁徙
个人简介
His research interests include cellular biology and genetics of cancer, specifically epigenetics or genetic modifications other than those in DNA that can affect cell behavior, and silencing of tumor suppressor genes and tumor progression. His research has looked at the mechanisms through which variations in tumor cells derive, and cell differentiation in cancers such as medullary thyroid carcinoma and small cell lung carcinoma.
Dr. Baylin’s honors include the 2004 National Investigator of the Year Award from the NCI SPORE program; the 2005 Jack Gibson Visiting Professorship, University of Hong Kong Queen Mary Hospital, Hong Kong; the 2005 Shubitz Cancer Research Prize from the University of Chicago; the 2008 Raffaele Tecce Memorial Lecture, Rome, Italy; the 2008 David Workman Memorial Award from the Waxman Foundation; the 2009 Kirk A. Landon-AACR Prize for Basic and Translational Cancer Research (jointly with Peter A. Jones, Ph.D.); the 2010 14th NCI Alfred G. Knudson Award in Cancer Genetics and the 2011 American Cancer Society’s Medal of Honor Award (jointly with Peter A. Jones, Ph.D.) and most recently the Fellows of The American Association of Cancer Research – Academy Class of 2014.
Dr. Baylin has served on the American Association for Cancer Research Board of Directors from 2004 through 2007, and is an associate editor of Cancer Research. He has also presented frequently at AACR conferences and chaired the special conference on “DNA Methylation, Imprinting and the Epigenetics of Cancer.” Dr. Baylin has authored or co-authored more than 400 publications.
In April 2017 Dr. Baylin was elected to the Association of American Physicians.
Our research has contributed heavily to the concept that epigenetically mediated loss of gene function is a major player in the progression of human cancer. This process, for which aberrant gene promoter hypermethylation is a signature and a component of aberrant loss of transcription for involved genes, is now known to be an alternative to coding region mutations for loss of function of more than half the classic tumor suppressor genes and for a growing list of candidate tumor suppressor genes in virtually every type of human cancer. We are attempting to understand the abnormalities of chromatin and methylation assembly that may account for the appearance of these epigenetic abnormalities during tumor development and how they mediate the transcriptional repression. We are learning, in this regard, that an interaction between the DNA methylation, histone de-acetylase (HDAC) and histone methylating enzymes mediates the transcriptional silencing. We have also discovered that the enzymes that catalyze DNA methylation, the DNA methyltransferases (DNMTs), are more complex than previously thought and can both inhibit transcription and interact with HDACs, independent of mediating the methylation. In collaboration with the Vogelstein-Kinzler lab, we have identified that an interaction between DNMTs is required in colon cancer cells to maintain the abnormal promoter methylation and silencing of important tumor suppressor genes. All of these studies are giving us a much more complete picture of the machinery that mediates aberrant promoter methylation in cancer. They also are contributing to the translational goal of targeting reversal of abnormal gene silencing as a cancer prevention and/or therapy strategy.
研究兴趣
论文共 919 篇作者统计合作学者相似作者
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Lora Stojanovic,Rachel Abbotts, Kaushlendra Tripathi, Collin M. Coon,Sheng Liu,Jun Wan,Michael J. Topper,Kenneth P. Nephew,Stephen B. Baylin,Feyruz V. Rassool
Cancer researchno. 5_Supplement_2 (2024): PR-005
Shi B Chia,Bryan J Johnson,Junxiao Hu,Roel Vermeulen,Marc Chadeau-Hyam, Fernando Guntoro,Hugh Montgomery,Meher Preethi Boorgula,Varsha Sreekanth,Andrew Goodspeed,Bennett Davenport, Felipe V Pereira,Vadym Zaberezhnyy,Wolfgang E Schleicher,Dexiang Gao,Andreia N Cadar,Michael Papanicolaou, Afshin Beheshti,Stephen B Baylin,James Costello,Jenna M Bartley,Thomas E Morrison,Julio A Aguirre-Ghiso,Mercedes Rincon,James DeGregori
Research square (2024)
Ronan J. Kelly,Blair V. Landon,Ali H. Zaidi,Dipika Singh,Jenna V. Canzoniero,Archana Balan,Russell K. Hales,K. Ranh Voong,Richard J. Battafarano,Blair A. Jobe,Stephen C. Yang,Stephen Broderick,Jinny Ha,Kristen A. Marrone,Gavin Pereira,Nisha Rao, Aryan Borole, Katerina Karaindrou,Zineb Belcaid,James R. White,Suqi Ke, Ali I. Amjad,Benny Weksler,Eun Ji Shin,Elizabeth Thompson,Kellie N. Smith,Drew M. Pardoll, Chen Hu,Josephine L. Feliciano,Valsamo Anagnostou,Vincent K. Lam
Nature medicine (2024)
Cancer Researchno. 6_Supplement (2024): 3219-3219
J. Tyson McDonald,JangKeun Kim, Lily Farmerie, Meghan L. Johnson,Nidia S. Trovao,Shehbeel Arif,Keith Siew,Sergey Tsoy,Yaron Bram,Jiwoon Park,Eliah Overbey,Krista Ryon,Jeffrey Haltom,Urminder Singh,Francisco J. Enguita,Victoria Zaksas,Joseph W. Guarnieri,Michael Topper,Douglas C. Wallace,Cem Meydan,Stephen Baylin,Robert Meller,Masafumi Muratani,D. Marshall Porterfield,Brett Kaufman,Marcelo A. Mori,Stephen B. Walsh,Dominique Sigaudo-Roussel,Saida Mebarek,Massimo Bottini, Christophe A. Marquette,Eve Syrkin Wurtele,Robert E. Schwartz,Diego Galeano,Christopher E. Mason,Peter Grabham,Afshin Beheshti
Nature communicationsno. 1 (2024)
Aidan S. Weitzner,Myan Bhoopalam,Jeffrey Khong,Arushi Biswas, Allison Karwoski, Meron Haile, Natalie Waldron, Resham Mawalkar, Anjana Srikumar,Stephen Broderick,Jinny Ha,Kristen P. Broderick
The Journal of surgical research/Journal of surgical research (2024): 137-144
Na Wang, Kara Lombardo, Raksha Padaki,Ray-Whay Chiu Yen,Malcolm V. Brock,Leslie Cope,Hariharan Easwaran,Stephen B. Baylin,Michelle Vaz
Cancer Researchno. 6_Supplement (2024): 1463-1463
Science Advancesno. 13 (2024)
Nature Communicationsno. 1 (2024): 1-11
Blair V. Landon, Guneet Kaleka,Archana Balan, Julia L. Boland,Christopher Cherry,Gavin Pereira,Cynthia Zahnow,Boris Winterhoff,Stephen Baylin,Victor E. Velculescu,Gottfried E. Konecny, John A. Glaspy,Valsamo Anagnostou
Cancer Researchno. 6_Supplement (2024): 7551-7551
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作者统计
#Papers: 917
#Citation: 150834
H-Index: 162
G-Index: 385
Sociability: 8
Diversity: 0
Activity: 4
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