He combines molecular and cellular biology with both biochemical and optical assays to generate quantitative data to build computational models of cellular processes. Research Interest Dr. Wiley's research interests are focused on understanding the systems-level design principles that underlie regulatory networks in both prokaryotic and eukaryotic cells. This work also focuses on how these regulatory networks become dysfunctional in diseases, such as cancer, and how they can be modified for both therapeutic and biological engineering applications. More recently, his work has focused on using new CRISPR-based technologies in combination with proteomics, gene expression and biochemical assays to build improved mechanistic models of signaling and metabolic networks. This work requires the creation of a scalable computational infrastructure for integrating multidimensional data sets as well as development of the underlying analytical technologies.