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个人简介
Dr. Stephen Tapscott studies how genes are turned on and off and how this activity goes awry in certain diseases. He focuses on the activity of certain “master” genes that control the development of muscle and nerve cells. He is a leader in understanding how the normal process of cell development is altered in two diseases: muscular dystrophy, a class of inherited diseases in which muscles weaken and atrophy over time; and rhabdomyosarcoma, a type of cancer that arises from muscle cells. Dr. Tapscott’s team made a breakthrough in unlocking the molecular secrets behind one of the most common forms of muscular dystrophy, facioscapulohumeral dystrophy, or FSHD. Dr. Tapscott found that in people with FSHD, proteins normally present in early development are erroneously activated in muscle cells, which prevents muscle-cell regeneration and possibly triggers a damaging immune attack against the muscles.
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论文共 285 篇作者统计合作学者相似作者
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The journal of cell biology/The Journal of cell biologyno. 5 (2024)
Lara Riem,Olivia DuCharme,Matthew Cousins, Xue Feng, Allison Kenney, Jacob Morris,Stephen J Tapscott,Rabi Tawil,Jeff Statland,Dennis Shaw,Leo Wang,Michaela Walker,Leann Lewis,Michael A Jacobs,Doris G Leung,Seth D Friedman,Silvia S Blemker
Scientific reportsno. 1 (2024): 15462-15462
Cold Spring Harbor perspectives in biology (2024)
HUMAN MOLECULAR GENETICSno. 8 (2024): 698-708
Human molecular geneticsno. 3 (2024): 284-298
bioRxiv the preprint server for biology (2023)
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#Papers: 286
#Citation: 24535
H-Index: 82
G-Index: 153
Sociability: 7
Diversity: 3
Activity: 29
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