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My laboratory focuses on the molecular basis of population heterogeneity in Mycobacterium tuberculosis (Mtb) and the extent to which differences between mycobacterial cells contribute to differences in disease and treatment outcomes. Our work combines bacterial genetic approaches with high throughput methodologies including population genomics, ssRNAseq and quantitative live cell imaging to define the molecular mechanisms by which Mtb generates diversity and how this diversity enables the bacterium to survive subsequent selective forces including antibiotics and immune selection. We further seek to understand the impact of host immune responses on the interaction of Mtb with the infected host, again working at both single cell and genomic levels. My work engages a broad network of collaborators including experts in technologies to assess single cell behavior at MIT and MGH, experts in sequencing methodologies at the Broad Institute and experts in human immunology at the Ragon Institute, where I am the outgoing Director of the TB Program.
Research Interests
Papers共 208 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
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期刊级别
合作者
合作机构
BRAINno. 9 (2024): 3247-3260
Infection and Immunityno. 4 (2024): e0053523-e0053523
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 14 (2024): e2403321121-e2403321121
Ming-Zhi Deng,Qingyun Liu, Shu-Jun Cui, Yi-Xin Wang, Guoliang Zhu, Han Fu,Mingyu Gan,Yuan-Yuan Xu,Xia Cai, Sheng Wang,Wei Sha,Guo-Ping Zhao,Sarah M Fortune,Liang-Dong Lyu
Proceedings of the National Academy of Sciences of the United States of Americano. 34 (2024): e2322938121-e2322938121
PLOS PATHOGENSno. 2 (2024)
PloS oneno. 5 (2024): e0302758-e0302758
Shobana Balasingam,Keertan Dheda,Sarah Fortune,Stephen B. Gordon,Daniel Hoft,James G. Kublin, Colleen N. Loynachan,Helen McShane,Ben Morton, Sujatha Nambiar,Nimisha Raj Sharma,Brian Robertson,Lewis K. Schrager,Charlotte L. Weller
JOURNAL OF INFECTIOUS DISEASESno. 2 (2024): e457-e464
Joshua M. Peters,Hannah P. Gideon,Travis K. Hughes, Cal Gunnarson,Pauline Maiello,Douaa Mugahid,Sarah K. Nyquist,Joshua D. Bromley,Paul C. Blainey,Beth F. Junecko, Molly L. Nelson,Douglas A. Lauffenburger,Philana Ling Lin,JoAnne L. Flynn,Alex K. Shalek,Sarah M. Fortune,Joshua T. Mattila,Bryan D. Bryson
crossref(2024)
Edward B. Irvine, Angel Nikolov, Mehak Z. Khan, Joshua M. Peters, Richard Lu, Jaimie Sixsmith, Aaron Wallace,Esther van Woudenbergh, Sally Shin, Wiktor Karpinski,Jeff C. Hsiao,Arturo Casadevall,Bryan D. Bryson, Lisa Cavacini, Patricia S. Grace,Galit Alter,Sarah M. Fortune
NATURE MICROBIOLOGY (2024)
Andrew W Simonson,Joseph J Zeppa,Allison N Bucsan,Michael C Chao,Supriya Pokkali,Forrest Hopkins,Michael R Chase,Andrew J Vickers,Matthew S Sutton,Caylin G Winchell,Amy J Myers,Cassaundra L Ameel,Ryan Kelly, Ben Krouse, Luke E Hood, Jiaxiang Li,Chelsea C Lehman,Megha Kamath,Jaime Tomko,Mark A Rodgers, Rachel Donlan, Harris Chishti,H Jacob Borish,Edwin Klein,Charles A Scanga,Sarah Fortune,Philana Ling Lin,Pauline Maiello,Mario Roederer,Patricia A Darrah,Robert A Seder,JoAnne L Flynn
bioRxiv : the preprint server for biology (2024)
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Author Statistics
#Papers: 209
#Citation: 12511
H-Index: 53
G-Index: 111
Sociability: 7
Diversity: 0
Activity: 2
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