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个人简介
The main areas of research interest are mutations and genomic aberrations associated with malignant transformation and pigmentation and malignant transformation, targeted therapy, and immunobiology of melanoma. Dr. Halaban and her colleagues characterized the mutational landscape of over 400 melanomas. They showed that NF1, a negative regulator of RAS, is the 3rd most frequently mutated gene in melanoma, after BRAF and NRAS. They identified a recurrent UV- signature, activating P29S mutation in RAC1 in 5% of sun-exposed melanomas. Furthermore, in acral melanomas, they revealed late-arising focal amplifications in chr22q11.21, which that include LZTR1 and CRKL, associated with poor outcomes and regional metastases. Most recently, they identified the immunological features associated with immune checkpoint inhibitors (ICI)-induced toxicity. They found that two pretreatment factors in circulation—activated CD4 memory T cell abundance and TCR diversity—are associated with severe irAE development regardless of organ system involvement.
研究兴趣
论文共 154 篇作者统计合作学者相似作者
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Bailey S.C.L. Jones,Patrick C. Demkowicz, Mitchelle Matesva, Renelle Pointdujour Lim,John H. Sinard,Antonietta Bacchiocchi,Ruth Halaban,Marcus Bosenberg,Mario Sznol,Harriet M. Kluger,Mathieu F. Bakhoum
biorxiv(2024)
EMBO MOLECULAR MEDICINEno. 9 (2024): 2188-2209
JOURNAL OF CLINICAL ONCOLOGYno. 16 (2024)
David Hafler,Benjamin Lu,Liliana Lucca,Wesley Lewis, Jiping Wang, Catarina Nogeuira,Sebastian Heer, Pierre-Paul Axisa, Nicholas Buitrago-Pocasangre, Giang Pham, Mina Kojima,Wei Wei,Lilach Aizenbud,Antonietta Bacchiocchi,Lin Zhang, Joseph Walewski,Veronica Chiang,Kelly Olino,James Clune,Ruth Halaban,Yuval Kluger,Anthony Coyle,Jan Kisielow,Franz-Josef Obermair,Harriet Kluger
Research square (2024)
JOURNAL FOR IMMUNOTHERAPY OF CANCERno. 3 (2024)
Madeleine Benguigui,Tim J. Cooper,Prajakta Kalkar, Sagie Schif-Zuck,Ruth Halaban,Antonella Bacchiocchi,Iris Kamer,Abhilash Deo,Bar Manobla,Rotem Menachem,Jozafina Haj-Shomaly,Avital Vorontsova,Ziv Raviv,Chen Buxbaum,Petros Christopoulos,Jair Bar,Michal Lotem,Mario Sznol,Amiram Ariel,Shai S. Shen-Orr,Yuval Shaked
CANCER CELLno. 2 (2024)
CANCER RESEARCHno. 6 (2024)
Oncotarget (2024): 507-520
Abul Usmani,Noah Earland,Wubing Zhang,Peter K. Harris,Antonietta Bacchiocchi, Chloe M. Sachs,Aishwarya Nene, David Y. Chen,Mario Sznol,Ruth Halaban,Aaron M. Newman,Aadel A. Chaudhuri
openalex
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作者统计
#Papers: 152
#Citation: 10155
H-Index: 48
G-Index: 100
Sociability: 7
Diversity: 0
Activity: 1
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