Pierre-Francois Roux

Cell fate decisions entail organized changes in gene expression. A fundamental question in biology is how genes and regulatory regions are organized and coordinated for transcription regulation in these processes. Recent findings, including those of the Bischof team, have demonstrated that alterations in chromatin architecture play a decisive role in gene-regulation, but their importance in cell-fate decisions is still unclear. To close this important gap in our knowledge, we seek to explore the role of chromatin structure changes in cellular senescence, a cell-fate crucial for tumor suppression and aging.