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个人简介
Group Leader: Dr Ronjon Chakraverty
Introduction
The Transplantation Immunology Group is based at the Hampstead Campus and forms part of a large Immunotherapy Programme at UCL. Our research involves both pre-clinical, translational and phase I/II projects that aim to develop innovative strategies to improve the anti-tumour effects of blood and bone marrow transplantation. We work closely with the groups of Professor Hans Stauss/Dr. Emma Morris (Tumour Immunology, Cellular and Gene Therapy), and Dr. Clare Bennett (Dendritic Cell Immunotherapy), with a number of fellows or PhD students working on joint projects.
Research
Following blood or bone marrow transplantation, donor T cells that have been infused as part of the graft or given at a later time point, become activated in response to antigenic differences between the donor and the recipient. This effect can be co-opted to generate anti-tumour activity, an effect termed the ‘graft-versus-tumour’ (GVT) response. Alternatively, donor T cells may react against normal tissues, leading to graft-versus-host disease (GVHD). See figure below:
Graft-versus-host-disease
These outcomes depend upon how donor T cells recognize antigen and this, in turn is influenced by nature of the cells presenting antigen. We are interested in how distinct non-haematopoietic and haematopoietic cell populations in the recipient influence the development of donor T cell immunity after transplantation. This research offers the opportunity to develop new approaches to manipulating antigen presentation for therapeutic benefit e.g. following vaccination.
Ultimately, durable anti-tumour immunity requires that T cells with anti-tumour reactivity engraft and then persist long-term in the recipient. By exploring clinically relevant models, we are examining the mechanisms that influence the long-term survival of anti-tumour T cells such that they can provide long-term immune surveillance. An improved understanding of the pathways that regulate this property of ‘memory’ is helping us to engineer T cells that can maintain their functions over long periods.
Introduction
The Transplantation Immunology Group is based at the Hampstead Campus and forms part of a large Immunotherapy Programme at UCL. Our research involves both pre-clinical, translational and phase I/II projects that aim to develop innovative strategies to improve the anti-tumour effects of blood and bone marrow transplantation. We work closely with the groups of Professor Hans Stauss/Dr. Emma Morris (Tumour Immunology, Cellular and Gene Therapy), and Dr. Clare Bennett (Dendritic Cell Immunotherapy), with a number of fellows or PhD students working on joint projects.
Research
Following blood or bone marrow transplantation, donor T cells that have been infused as part of the graft or given at a later time point, become activated in response to antigenic differences between the donor and the recipient. This effect can be co-opted to generate anti-tumour activity, an effect termed the ‘graft-versus-tumour’ (GVT) response. Alternatively, donor T cells may react against normal tissues, leading to graft-versus-host disease (GVHD). See figure below:
Graft-versus-host-disease
These outcomes depend upon how donor T cells recognize antigen and this, in turn is influenced by nature of the cells presenting antigen. We are interested in how distinct non-haematopoietic and haematopoietic cell populations in the recipient influence the development of donor T cell immunity after transplantation. This research offers the opportunity to develop new approaches to manipulating antigen presentation for therapeutic benefit e.g. following vaccination.
Ultimately, durable anti-tumour immunity requires that T cells with anti-tumour reactivity engraft and then persist long-term in the recipient. By exploring clinically relevant models, we are examining the mechanisms that influence the long-term survival of anti-tumour T cells such that they can provide long-term immune surveillance. An improved understanding of the pathways that regulate this property of ‘memory’ is helping us to engineer T cells that can maintain their functions over long periods.
研究兴趣
论文共 209 篇作者统计合作学者相似作者
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crossref(2023)
Morgane Cheminant,Thomas A. Fox,Mickael Alligon,Olivier Bouaziz,Benedicte Neven,Despina Moshous,Stephane Blanche,Aurelien Guffroy,Claire Fieschi,Marion Malphettes,Nicolas Schleinitz,Antoinette Perlat,Jean-Francois Viallard,Nathalie Dhedin,Francoise Sarrot-Reynauld,Isabelle Durieu,Sebastien Humbert,Fanny Fouyssac,Vincent Barlogis,Benjamin Carpenter,Rachael Hough,Arian Laurence,Ambroise Marcais,Ronjon Chakraverty,Olivier Hermine,Alain Fischer,Siobhan O. Burns,Nizar Mahlaoui,Emma C. Morris,Felipe Suarez
BMJ openno. 6 (2023): e067790-e067790
Bloodno. Supplement 1 (2023): 654-654
Charles Craddock,David Marks,Victoria Potter,Wendy A. Ingram, Rebecca Collings,Eleni Tholouli,Rachel Protheroe, Hugh Allen, Alex Ross, Dawn Farrar,Shamyla Siddique,Rebecca Bishop,Ronjon Chakraverty
Bloodno. Supplement 1 (2023): 5097-5097
W. Ingram, R. Collings, A. Jackson,R. Protheroe,V. Potter,F. Dignan,E. Hurst,C. Crawley,P. Kottaridis,C. Gaskell,R. Chakraverty, E. Williams,R. Bishop,C. Craddock
BONE MARROW TRANSPLANTATIONno. SUPPL 1 (2022)
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Practical Transfusion Medicinepp.543-553, (2022)
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#Papers: 208
#Citation: 7651
H-Index: 40
G-Index: 86
Sociability: 7
Diversity: 0
Activity: 1
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