RESEARCH INTERESTS
Circulating immune cells must exit blood vessels near specific target sites of injury, inflammation or tissue repair. The vessel wall at these sites displays specific combinations of traffic signals which operate in sequence to recruit only specific circulating subsets with proper receptors to these signals. As these processes take place under shear stress, we use special flow chambers which simulate blood flow and intravital microscopy in genetically manipulated mice, together with state of the art 3D imaging techniques, to dissect how endothelial and perivascular trafficking molecules promote context- and tissue- selective exit of immune cells through distinct blood vessels.