Humphries is passionate about clinical microbiology and antimicrobial resistance in particular. Having spent several years in diagnostic industry, she is a champion for the development of novel diagnostic tests for infectious diseases to transform how patients with infections are managed. She is an editor for the Journal of Clinical Microbiology, and a member of the Clinical and Laboratory Standards Institute (CLSI) Antibiotic Susceptibility Testing (AST) Subcommittee, the College of American Pathologists (CAP) Microbiology Committee, the American Society for Microbiology (ASM) Professional Practices Committee, and vice-chair of the Infectious Diseases Society of America Diagnostics Committee.