An ISI highly cited researcher, he has over 200 refereed publications, notably on methods for the analysis of data with missing values and model-based survey inference, and the application of statistics to diverse scientific areas, including medicine, demography, economics, psychiatry, aging and the environment. He has chaired or co-chaired 29 doctoral committees. In 2005 Dr. Little received the Wilks' Memorial Award from the American Statistical Association for his research contributions. At the Joint Statistical Meetings, he gave the President's Invited Address in 2005 and the COPSS Fisher lecture in 2012.