My research is focused on elucidating the cellular and molecular mechanisms underlying natural and therapeutically induced immune responses to developing and established cancers. My group was the first to propose the concept of “Cancer Immunoediting” wherein the immune system not only protects against cancer but also favors cancer outgrowth by shaping tumor cell immunogenicity. We went on to provide strong experimental evidence supporting each of the three phases of the cancer immunoediting process—Elimination, Equilibrium and Escape. We produced a variety of gene-targeted mice and used them to obtain genetic evidence for the roles of various cytokines, receptors and signaling pathways in the cancer immunoediting process. In the process, we also developed a model of mouse mammary cancer that displays remarkable similarities to human luminal breast cancer. During my career, my lab generated a number of key monoclonal antibody reagents that neutralize cytokines or block cytokine receptors and validated their in vivo use to assess the role of cytokines in preventing or inducing diseases particularly cancer.