Dr. Wolf's research focus is on clinical care innovations to improve outcomes in pediatric diabetes. She is the Principal Investigator of a study implementing point-of-care diabetes retinopathy screening into pediatric diabetes care, a Co-Investigator for Trialnet, and the Principal Investigator for the Pediatric Diabetes Consortium site at Johns Hopkins. She also studies a novel family of proteins, called CTRPs, to determine their impact on glucose and lipid metabolism in the context of obesity and diabetes.

She is board certified in pediatrics and pediatric endocrinology. Dr. Wolf is affiliated with the American Academy of Pediatrics, the Pediatric Endocrine Society, the Endocrine Society, and the American Diabetes Association.