He and his colleagues were the first to utilize bronchoalveolar lavage (BAL) to characterize scleroderma lung disease. He played an instrumental role in the design and development of the Scleroderma Lung Study I and II. Dr. Silver helped to initiate and develop MUSC’s pulmonary hypertension center and sarcoidosis center. Dr. Silver serves as associate director of a multidisciplinary clinical research center (MCRC) for the study of rheumatic diseases in African-Americans funded by NIAMS. Dr. Silver’s clinical interests include scleroderma and scleroderma-related conditions, as well as childhood rheumatic diseases. MUSC Health is one of the world’s leaders in clinical care and investigation of systemic sclerosis (scleroderma) and scleroderma-like conditions, e.g. eosinophilic fasciitis and the eosinophilia-myalgia syndrome. MUSC Health also serves as the state of South Carolina's only referral center for childhood rheumatic diseases. Dr. Silver has led the efforts to coordinate care for children in South Carolina with rheumatic diseases for the past 32 years,FALSE, and he continues to provide clinical care and conduct clinical research with Dr. Tasha Ruth, whose primary appointment is in the Department of Pediatrics.