基本信息
浏览量:6
职业迁徙
个人简介
The Trievel laboratory uses a combination of biochemical and biophysical approaches to study the structures, mechanisms, and substrate specificities of a variety of enzymes, particularly lysine methyltransferases. Current projects include:
Structural and Functional Studies of Histone Methylation. Histone lysine methyltransferases (KMTs) and lysine demethylases (KDMs) establish and maintain chromatin methylation states that play a fundamental role in regulating transcription and other genomic processes. Our laboratory has characterized the molecular determinants of the substrate specificities of several human KMTs and KDMs utilizing crystallographic and biochemical methods. More recently, we have initiated a new research program aimed at understanding the functions of KMTs expressed by bacterial pathogens. Theses enzymes are secreted by the pathogens into host cells where they enter the nucleus and catalyze histone lysine methylation, hijacking host gene expression to promote bacterial replication. Structural and functional characterization of KMTs from Legionella pneumophila, the primary causative agent of Legionnaires’ Disease, is yielding new insights into the molecular basis of their unique histone lysine specificity. Together, these studies are illuminating new aspects of host-pathogen interactions and represent an emerging area of research at the interface of chromatin biology and microbiology.
Structural and Functional Studies of Histone Methylation. Histone lysine methyltransferases (KMTs) and lysine demethylases (KDMs) establish and maintain chromatin methylation states that play a fundamental role in regulating transcription and other genomic processes. Our laboratory has characterized the molecular determinants of the substrate specificities of several human KMTs and KDMs utilizing crystallographic and biochemical methods. More recently, we have initiated a new research program aimed at understanding the functions of KMTs expressed by bacterial pathogens. Theses enzymes are secreted by the pathogens into host cells where they enter the nucleus and catalyze histone lysine methylation, hijacking host gene expression to promote bacterial replication. Structural and functional characterization of KMTs from Legionella pneumophila, the primary causative agent of Legionnaires’ Disease, is yielding new insights into the molecular basis of their unique histone lysine specificity. Together, these studies are illuminating new aspects of host-pathogen interactions and represent an emerging area of research at the interface of chromatin biology and microbiology.
研究兴趣
论文共 121 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Isaiah Odeyemi, Teri A. Douglas, Nosakhare F. Igie,James A. Hargrove,Grace Hamilton, Brianna B. Bradley, Cathy Thai,Brendan Le, Maitri Unjia, Dylan Wicherts, Zackery Ferneyhough,Anjali Pillai,Shailendra Koirala,Laurel M. Hagge,Himanshu Polara,Raymond C. Trievel,Robert J. Fick,Allison L. Stelling
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy (2024)
Spencer A. Haws, Lillian J. Miller, Diego Rojas La Luz,Vyacheslav I. Kuznetsov,Raymond C. Trievel,Gheorghe Craciun,John M. Denu
JOURNAL OF BIOLOGICAL CHEMISTRYno. 7 (2023)
Brianna Bradley,Grace Hamilton, Teri Douglas,Anjali Pillai,Robert Fick, Drew Hargrove,Brendan Le, Maitri Unjia,Raymond Trievel,Allison Stelling
Shane M. Ginnard,Alyssa E. Winkler,Carlos Mellado Fritz,Tatum Bluhm,Ray Kemmer,Marisa Gilliam,Nick Butkevich,Sara Abdrabbo,Kaitlyn Bricker,Justin Feiler,Isaak Miller,Jenna Zoerman,Zeineb El-Mohri,Panida Khuansanguan,Madyson Basch,Timothy Petzold,Matthew Kostoff,Sean Konopka,Brendon Kociba,Thomas Gillis,Deborah L. Heyl,Raymond C. Trievel,Brittany N. Albaugh
Shane M. Ginnard,Alyssa E. Winkler,Carlos Mellado Fritz,Tatum Bluhm,Ray Kemmer,Marisa Gilliam,Nick Butkevich,Sara Abdrabbo,Kaitlyn Bricker,Justin Feiler,Isaak Miller,Jenna Zoerman,Zeineb El-Mohri,Panida Khuansanguan,Madyson Basch,Timothy Petzold,Matthew Kostoff,Sean Konopka,Brendon Kociba,Thomas Gillis,Deborah L. Heyl,Raymond C. Trievel,Brittany N. Albaugh
Proteins (2021)
加载更多
作者统计
#Papers: 123
#Citation: 6731
H-Index: 40
G-Index: 70
Sociability: 6
Diversity: 2
Activity: 4
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn