I have a long standing interest focused in understanding the way how therapeutic hypothermia (TH) works in a full-term model of neonatal hypoxic-ischemic (HI) brain injury to be able to target aspect that are not fully addressed by this therapy with the ultimate goal to improve neurodevelopmental outcomes of newborns surviving HI encephalopathy. Neonatal HI brain injury produces delayed disruption of the maturation of hippocampal interneurons not prevented by TH (Hippocampus 2018; 28(8):617-630. PMID 29781223). My laboratory is currently working in characterizing the functional (Neuroscience, Mar 2019. PMID 30849447; Dev Neurosci, Feb 2019. PMID 30820019; Dev Neurosci, Mar 2019. PMID 30861522) and electrophysiological deficits that follow and the mechanism involving alterations of ErbB4.