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My laboratory works on understanding the mechanisms by which cells sense and signal hypoxia (low oxygen levels). Oxygen is of fundamental importance for most living organisms, and the maintenance of oxygen homeostasis is a central physiological challenge for all large animals. Hypoxia is an important component of many human diseases including cancer, heart disease, stroke, vascular disease, and anaemia.
Working initially on regulation of the haematopoietic growth factor erythropoietin (which shows strong transcriptional upregulation by hypoxia), the laboratory discovered that the underlying oxygen sensitive signal pathway is widely operative in mammalian cells, extends to invertebrates, and mediates a range of other transcriptional responses including those regulating angiogenesis and metabolism. The laboratory went to define the oxygen sensing and signalling pathways that link the essential transcription factor, hypoxia inducible factor (HIF) to the availability of oxygen.
Working initially on regulation of the haematopoietic growth factor erythropoietin (which shows strong transcriptional upregulation by hypoxia), the laboratory discovered that the underlying oxygen sensitive signal pathway is widely operative in mammalian cells, extends to invertebrates, and mediates a range of other transcriptional responses including those regulating angiogenesis and metabolism. The laboratory went to define the oxygen sensing and signalling pathways that link the essential transcription factor, hypoxia inducible factor (HIF) to the availability of oxygen.
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Samvid Kurlekar, Joanna D C C Lima,Ran Li,Olivia Lombardi,Norma Masson, Ayslan B Barros, Virginia Pontecorvi,David R Mole, Christopher W Pugh,Julie Adam,Peter J Ratcliffe
Cancer researchno. 11 (2024): 1799-1816
Samvid Kurlekar, Joanna D.C.C. Lima,Ran Li,Olivia Lombardi,Norma Masson, Ayslan B. Barros, Virginia Pontecorvi,David R. Mole,Christopher W. Pugh,Julie Adam,Peter J. Ratcliffe
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Jingyi Ma,Khatoun Al Moussawi,Hantao Lou, Hok Fung Chan,Yihua Wang, Joseph Chadwick,Chansavath Phetsouphanh,Elizabeth A. Slee,Shan Zhong,Thomas M. Leissing,Andrew Roth,Xiao Qin,
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 10 (2024): e2309957121-e2309957121
Samvid Kurlekar, Joanna D.C.C. Lima,Ran Li,Olivia Lombardi,Norma Masson, Ayslan B. Barros, Virginia Pontecorvi,David R. Mole,Christopher W. Pugh,Julie Adam,Peter J. Ratcliffe
crossref(2024)
Samvid Kurlekar, Joanna D.C.C. Lima,Ran Li,Olivia Lombardi,Norma Masson, Ayslan B. Barros, Virginia Pontecorvi,David R. Mole,Christopher W. Pugh,Julie Adam,Peter J. Ratcliffe
crossref(2024)
Joanna Lima,Samvid Kurlekar,Norma Masson, Ayslan B. Barros,Maria Fernanda Soares,Christopher W. Pugh,Julie Adam,Peter J. Ratcliffe
Cancer Researchno. 6_Supplement (2024): 6622-6622
Cancer Researchno. 6_Supplement (2024): 6944-6944
Samvid Kurlekar, Joanna D.C.C. Lima,Ran Li,Olivia Lombardi,Norma Masson, Ayslan B. Barros, Virginia Pontecorvi,David R. Mole,Christopher W. Pugh,Julie Adam,Peter J. Ratcliffe
crossref(2024)
Samvid Kurlekar, Joanna D.C.C. Lima,Ran Li,Olivia Lombardi,Norma Masson, Ayslan B. Barros, Virginia Pontecorvi,David R. Mole,Christopher W. Pugh,Julie Adam,Peter J. Ratcliffe
crossref(2024)
Samvid Kurlekar, Joanna D.C.C. Lima,Ran Li,Olivia Lombardi,Norma Masson, Ayslan B. Barros, Virginia Pontecorvi,David R. Mole,Christopher W. Pugh,Julie Adam,Peter J. Ratcliffe
crossref(2024)
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