Major Areas of Research
Study pathogenesis and immune-dysregulatory mechanisms of interleukin (IL)-1-mediated autoinflammatory diseases including NOMID, DIRA, and the IL-1/IL-18-mediated disease NLRC4-MAS
Study pathogenesis and immune-dysregulatory mechanisms of Type I interferon (IFN)-mediated autoinflammatory diseases including CANDLE and SAVI
Identify molecular and genetic causes (using next-generation sequencing methods) of yet undifferentiated autoinflammatory diseases
Translate the knowledge gained from the pathogenesis evaluations into finding drug targets for better treatment approaches
Implement pilot treatment studies with targeted therapeutics to evaluate efficacy (control of organ inflammation and prevention of organ damage) and drug safety