基本信息
浏览量:6
职业迁徙
个人简介
Research Focus
HIV-1 Envelope Glycoprotein Structure and Immunogenicity
The human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of AIDS causing a huge toll of human malaise and morbidity. Although a substantial arsenal of drugs can treat this devastating disease, a broadly effective vaccine remains the most cost-effective way to halt further spread of this virus in the human population. However, due to the approximately 32 million infected individuals already infected in the human population world-wide, and the incredible diversity of this virus in the individual and the population, such a vaccine has proven difficult to develop. Because most viral vaccines protect against disease by neutralizing antibodies, we study the HIV-1 envelope glycoproteins (Env) as antigens, as immunogens and at the atomic level of structural refinement to gain insight in how to better elicit antibodies directed against these external, variable and heavily glycosylated neutralizing determinants. We make specialized Env variants and analyze their biochemical and biophysical features, use them as probes to isolate new and novel broadly neutralizing antibodies and assess their immunogenicity all as part of the plan to better elicit neutralizing antibodies by rational, structure-guided vaccine design.
HIV-1 Envelope Glycoprotein Structure and Immunogenicity
The human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of AIDS causing a huge toll of human malaise and morbidity. Although a substantial arsenal of drugs can treat this devastating disease, a broadly effective vaccine remains the most cost-effective way to halt further spread of this virus in the human population. However, due to the approximately 32 million infected individuals already infected in the human population world-wide, and the incredible diversity of this virus in the individual and the population, such a vaccine has proven difficult to develop. Because most viral vaccines protect against disease by neutralizing antibodies, we study the HIV-1 envelope glycoproteins (Env) as antigens, as immunogens and at the atomic level of structural refinement to gain insight in how to better elicit antibodies directed against these external, variable and heavily glycosylated neutralizing determinants. We make specialized Env variants and analyze their biochemical and biophysical features, use them as probes to isolate new and novel broadly neutralizing antibodies and assess their immunogenicity all as part of the plan to better elicit neutralizing antibodies by rational, structure-guided vaccine design.
研究兴趣
论文共 219 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Javier Guenaga, Mehrdad Alirezaei, Yu Feng,Mohamad-Gabriel Alameh,Wen-Hsin Lee,Sabyasachi Baboo, Jocelyn Cluff,Richard Wilson, Shridhar Bale,Gabriel Ozorowski,Paulo Lin,Ying Tam,Jolene K. Diedrich,John R. Yates III,James C. Paulson,Andrew B. Ward,Drew Weissman,Richard T. Wyatt
FRONTIERS IN IMMUNOLOGY (2024)
FRONTIERS IN IMMUNOLOGY (2023)
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V (2023): 112-125
Safia S. Aljedani,Tyler J. Liban,Karen Tran,Ganesh Phad,Suruchi Singh,Viktoriya Dubrovskaya,Pradeepa Pushparaj,Paola Martinez-Murillo,Justas Rodarte,Alex Mileant,Vidya Mangala Prasad, Rachel Kinzelman,Sijy O'Dell,John R. Mascola,Kelly K. Lee,Gunilla B. Karlsson Hedestam,Richard T. Wyatt,Marie Pancera
openalex(2021)
Cell Reports (2020): 3964-3971.e7
加载更多
作者统计
#Papers: 219
#Citation: 20441
H-Index: 54
G-Index: 142
Sociability: 7
Diversity: 0
Activity: 0
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn